| Also known as: |
BAX |
| Other names: |
Apoptosis regulator BAX, BCL2-associated X protein, BCL2-associated X protein omega, BCL2-associated X protein transcript variant delta2, Bcl-2-like protein 4, apoptosis regulator BAX, bcl-2-like protein 4, bcl2-L-4, apoptosis regulator BAX isoform beta |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
BAX |
| Other gene names: |
BAX, BCL2L4, BCL2L4, Bcl2-L-4, BAX |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
2D2 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
BAX accelerates programmed cell death by binding to and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein, Burkitt lymphoma, Defects in BAX are found in some cell lines from hematopoietic malignancies as T-cell acute lymphoblastic leukemia, It also induces the release of cytochrome C, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, a proapoptotic member of the Bcl-2 family, activation of CASP3 and thereby apoptosis, and plasmacytoma, BAX This item specifically recognises an epitope within the N-terminal (NT) region of human BAX, _x000D__x000D_ |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Immunofluorescence (IF), Immunoprecipitation (IP), Western Blot (WB), ELISA (EIA) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
BAX |
| Short name: |
MOUSE Anti-HUMAN BAX (N-TERMINAL) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens BCL2-associated X protein (N-TERMINAL) (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BAX and IDBG-61459 and ENSG00000087088 and 581, BAX and IDBG-640344 and ENSBTAG00000013340 and 100850136, BCL2L4, BH3 domain binding, Bax and IDBG-183241 and ENSMUSG00000003873 and 12028, nuclei, this GO :0001541 and ovarian follicle development and biological process this GO :0001764 and neuron migration and biological process this GO :0001776 and leukocyte homeostasis and biological process this GO :0001777 and T cell homeostatic proliferation and biological process this GO :0001782 and B cell homeostasis and biological process this GO :0001783 and B cell apoptotic process and biological process this GO :0001822 and kidney development and biological process this GO :0001836 and release of cytochrome c from mitochondria and biological process this GO :0001844 and protein insertion into mitochondrial membrane involved in apoptotic signaling pathway and biological process this GO :0001974 and blood vessel remodeling and biological process this GO :0002262 and myeloid cell homeostasis and biological process this GO :0002352 and B cell negative selection and biological process this GO :0002358 and B cell homeostatic proliferation and biological process this GO :0002904 and positive regulation of B cell apoptotic process and biological process this GO :0005515 and protein binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005739 and mitochondrion and cellular component this GO :0005741 and mitochondrial outer membrane and cellular component this GO :0005757 and mitochondrial permeability transition pore complex and cellular component this GO :0005783 and endoplasmic reticulum and cellular component this GO :0005789 and endoplasmic reticulum membrane and cellular component this GO :0005829 and cytosol and cellular component this GO :0006687 and glycosphin this GO lipid metabolic process and biological process this GO :0006808 and regulation of nitrogen utilization and biological process this GO :0006915 and apoptotic process and biological process this GO :0006919 and activation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0006927 and transformed cell apoptotic process and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0007281 and germ cell development and biological process this GO :0007283 and spermatogenesis and biological process this GO :0007399 and nervous system development and biological process this GO :0007548 and sex differentiation and biological process this GO :0008053 and mitochondrial fusion and biological process this GO :0008283 and cell proliferation and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008289 and lipid binding and molecular function this GO :0008584 and male this GO nad development and biological process this GO :0008625 and extrinsic apoptotic signaling pathway via death domain receptors and biological process this GO :0008630 and intrinsic apoptotic signaling pathway in response to DNA damage and biological process this GO :0008635 and activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c and biological process this GO :0008637 and apoptotic mitochondrial changes and biological process this GO :0009566 and fertilization and biological process this GO :0009611 and response to wounding and biological process this GO :0009636 and response to toxic substance and biological process this GO :0009651 and response to salt stress and biological process this GO :0009791 and post-embryonic development and biological process this GO :0010212 and response to ionizing radiation and biological process this GO :0010248 and establishment or maintenance of transmembrane electrochemical gradient and biological process this GO :0010332 and response to gamma radiation and biological process this GO :0010524 and positive regulation of calcium ion transport into cytosol and biological process this GO :0015267 and channel activity and molecular function this GO :0016020 and membrane and cellular component this GO :0016032 and viral process and biological process this GO :0021854 and hypothalamus development and biological process this GO :0021987 and cerebral cortex development and biological process this GO :0031966 and mitochondrial membrane and cellular component this GO :0032091 and negative regulation of protein binding and biological process this GO :0032461 and positive regulation of protein oli this GO merization and biological process this GO :0032469 and endoplasmic reticulum calcium ion homeostasis and biological process this GO :0032471 and negative regulation of endoplasmic reticulum calcium ion concentration and biological process this GO :0032976 and release of matrix enzymes from mitochondria and biological process this GO :0033137 and negative regulation of peptidyl-serine phosphorylation and biological process this GO :0033599 and regulation of mammary gland epithelial cell proliferation and biological process this GO :0034644 and cellular response to UV and biological process this GO :0035108 and limb morphogenesis and biological process this GO :0035234 and ectopic germ cell programmed cell death and biological process this GO :0042475 and odontogenesis of dentin-containing tooth and biological process this GO :0042802 and identical protein binding and molecular function this GO :0042803 and protein homodimerization activity and molecular function this GO :0042981 and regulation of apoptotic process and biological process this GO :0043065 and positive regulation of apoptotic process and biological process this GO :0043281 and regulation of cysteine-type endopeptidase activity involved in apoptotic process and biological process this GO :0043496 and regulation of protein homodimerization activity and biological process this GO :0043497 and regulation of protein heterodimerization activity and biological process this GO :0043523 and regulation of neuron apoptotic process and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0043525 and positive regulation of neuron apoptotic process and biological process this GO :0043653 and mitochondrial fragmentation involved in apoptotic process and biological process this GO :0045136 and development of secondary sexual characteristics and biological process this GO :0046666 and retinal cell programmed cell death and biological process this GO :0046930 and pore complex and cellular component this GO :0046982 and protein heterodimerization activity and molecular function this GO :0048087 and positive regulation of developmental pigmentation and biological process this GO :0048147 and negative regulation of fibroblast proliferation and biological process this GO :0048515 and spermatid differentiation and biological process this GO :0048597 and post-embryonic camera-type eye morphogenesis and biological process this GO :0048678 and response to axon injury and biological process this GO :0048872 and homeostasis of number of cells and biological process this GO :0048873 and homeostasis of number of cells within a tissue and biological process this GO :0051259 and protein oli this GO merization and biological process this GO :0051260 and protein homooli this GO merization and biological process this GO :0051281 and positive regulation of release of sequestered calcium ion into cytosol and biological process this GO :0051402 and neuron apoptotic process and biological process this GO :0051434 and BH3 domain binding and molecular function this GO :0051726 and regulation of cell cycle and biological process this GO :0051881 and regulation of mitochondrial membrane potential and biological process this GO :0060011 and Sertoli cell proliferation and biological process this GO :0060041 and retina development in camera-type eye and biological process this GO :0060058 and positive regulation of apoptotic process involved in mammary gland involution and biological process this GO :0060068 and vagina development and biological process this GO :0070059 and intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0070242 and thymocyte apoptotic process and biological process this GO :0070584 and mitochondrion morphogenesis and biological process this GO :0071310 and cellular response to organic substance and biological process this GO :0072332 and intrinsic apoptotic signaling pathway by p53 class mediator and biological process this GO :0090200 and positive regulation of release of cytochrome c from mitochondria and biological process this GO :0097136 and Bcl-2 family protein complex and cellular component this GO :0097144 and BAX complex and cellular component this GO :0097190 and apoptotic signaling pathway and biological process this GO :0097191 and extrinsic apoptotic signaling pathway and biological process this GO :0097192 and extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process this GO :0097296 and activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway and biological process this GO :1900103 and positive regulation of endoplasmic reticulum unfolded protein response and biological process this GO :1901030 and positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway and biological process this GO :1902108 and regulation of mitochondrial membrane permeability involved in apoptotic process and biological process this GO :1902110 and positive regulation of mitochondrial membrane permeability involved in apoptotic process and biological process this GO :1902262 and apoptotic process involved in patterning of blood vessels and biological process this GO :1902263 and apoptotic process involved in embryonic digit morphogenesis and biological process this GO :1902445 and regulation of mitochondrial membrane permeability involved in programmed necrotic cell death and biological process this GO :1902512 and positive regulation of apoptotic DNA fragmentation and biological process this GO :1990009 and retinal cell apoptotic process and biological process this GO :1990117 and B cell receptor apoptotic signaling pathway and biological process this GO :2001234 and negative regulation of apoptotic signaling pathway and biological process this GO :2001241 and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand and biological process this GO :2001244 and positive regulation of intrinsic apoptotic signaling pathway and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0008289 : lipid binding and also this GO :0015267 : channel activity and also this GO :0042802 : identical protein binding and also this GO :0042803 : protein homodimerization activity and also this GO :0046982 : protein heterodimerization activity and also this GO :0051434 : BH3 domain binding, this GO :0008289 : lipid binding, this GO :0015267 : channel activity, this GO :0042802 : identical protein binding, this GO :0042803 : protein homodimerization activity, this GO :0046982 : protein heterodimerization activity, this GO :0051434 : BH3 domain binding, 280730, BCL2-associated X protein |
| Identity: |
959 |
| Gene: |
BAX |
More about : BAX |
| Long gene name: |
BCL2 associated X, apoptosis regulator |
| Synonyms gene name: |
BCL2-associated X protein BCL2 associated X protein |
| Synonyms: |
BCL2L4 |
| Locus: |
19q13, 33 |
| Discovery year: |
1994-11-08 |
| Entrez gene record: |
581 |
| Pubmed identfication: |
8358790 |
| RefSeq identity: |
NM_138763 |
| Classification: |
BCL2 family |
| Havana BLAST/BLAT: |
OTTHUMG00000160476 |