| Also known as: |
COMPLEMENT FACTOR I |
| Other names: |
C3B/C4B inactivator, C3B/C4B inactivator, C3b-inactivator, Complement factor I, Konglutinogen-activating factor, complement component I, complement control protein factor I, complement factor I, complement factor I, complement factor I heavy chain, light chain of factor I, complement factor I preproprotein |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
AHUS3, C3BINA, C3b-INA, CFI, FI, IF, IF, KAF, CFI |
| Gene name synonims: |
AHUS3, C3BINA, C3b-INA, CFI, FI, IF, IF, KAF, CFI |
| Other gene names: |
AHUS3, C3BINA, C3b-INA, CFI, FI, IF, IF, KAF, CFI |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
3R/8 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
, C3b cleavage requires the presence of cofactors complement component (3b/4b) receptor 1 (CR1), Defects in CFI are also associated with haemolytic uraemic syndrome, Factor I has no natural inhibitors, Factor I is a serine protease which inactivates complement components C3b and C4b, Factor I is an 88 kDa protein consisting of one polypeptide chain of 35, Removal of Sodium Azide is recommended prior to use in functional assays, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, _x000D__x000D_Dysfunctional factor I can lead to uncontrolled activation of the alternative complement pathway causing in systemic depletion of C3 and lower levels of factors B and H, _x000D__x000D_This item blocks function of complement factor I, a member of the peptidase S1 family present in the blood plasma, membrane cofactor protein or factor H, resulting in recurrent pyogenic infections, while C4b cleavage requires complement component 4 binding protein or CR1, 4 kDa and one of 27, 6 kDa, COMPLEMENT FACTOR I This item recognises complement factor I |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
ELISA (EIA), Functional Assay (FA), Immunohistology - Frozen (IHC), Western Blot (WB) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
COMPLEMENT FACTOR I |
| Short name: |
MOUSE Anti-HUMAN COMPLEMENT FACTOR I Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens COMPLEMENT FACTOR I (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
5394 |
| Gene: |
CFI |
More about : CFI |
| Long gene name: |
complement factor I |
| Synonyms gene: |
IF |
| Synonyms gene name: |
I factor (complement) |
| Synonyms: |
FI C3b-INA KAF |
| Synonyms name: |
Konglutinogen-activating factor C3b-inactivator |
| Locus: |
4q25 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
J02770 |
| Entrez gene record: |
3426 |
| Pubmed identfication: |
2956252 |
| RefSeq identity: |
NM_000204 |
| Classification: |
Complement system |
| Havana BLAST/BLAT: |
OTTHUMG00000161109 |
| Locus Specific Databases: |
CFIbase: Mutation registry for Factor I deficiency (previously known as IFbase) LRG_48 |