| Also known as: |
COMPLEMENT FACTOR H |
| Other names: |
Complement factor H, H factor 1, H factor 1 (complement), H factor 2 (complement), adrenomedullin binding protein, age-related maculopathy susceptibility 1, beta-1-H-globulin, beta-1H, complement factor H, complement factor H, complement factor H, factor H-like 1, isoform b, complement factor H isoform a |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
AHUS1, AMBP1, ARMD4, ARMS1, CFH, CFHL3, FH, FHL1, HF, HF, HF1, HF1, HF2, HF2, HUS, CFH |
| Gene name synonims: |
AHUS1, AMBP1, ARMD4, ARMS1, CFH, CFHL3, FH, FHL1, HF, HF, HF1, HF1, HF2, HF2, HUS, CFH |
| Other gene names: |
AHUS1, AMBP1, ARMD4, ARMS1, CFH, CFHL3, FH, FHL1, HF, HF, HF1, HF1, HF2, HF2, HUS, CFH |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
42287 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
Factor H also inhibits the formation of the C3bBb complex (C3 convertase) and increases the rate of dissociation of both C3 convertase and the (C3b)NBB complex (C5 convertase), Factor H is secreted by the liver into the blood serum, It is important in regulating the complement pathway, It makes C3b susceptible to cleavage by factor I, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The most common form, This particular antibody might cross react with speacies outside of the listed ones, This prevents these components of the classical and of alternative complement pathways from forming a positive feedback loop, _x000D__x000D_Complement factor H functions as a cofactor in the inactivation of C3b by factor I, _x000D__x000D_Mutations in factor H are associated with hemolytic-uremic syndrome, age-related macular degeneration, and the less common form of 43 kDa, membranoproliferative glomerulonephritis (MPGN) type II and chronic hypocomplementemic nephropathy, of 150 kDa, preventing unnecessary inflammation which can damage the host tissue, resulting in iC3b, COMPLEMENT FACTOR H This item recognises human complement factor H which exists in 2 forms |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
ELISA (EIA), Flow Cytometry (FACS), Immunohistology - Frozen (IHC), Western Blot (WB) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
COMPLEMENT FACTOR H |
| Short name: |
MOUSE Anti-HUMAN COMPLEMENT FACTOR H Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens COMPLEMENT FACTOR H (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
4890 |
| Gene: |
CFHR2 |
More about : CFHR2 |
| Long gene name: |
complement factor H related 2 |
| Synonyms gene: |
HFL3 CFHL2 |
| Synonyms gene name: |
H factor (complement)-like 3 complement factor H-related 2 |
| Synonyms: |
FHR2 |
| Locus: |
1q31, 3 |
| Discovery year: |
1993-10-18 |
| GenBank acession: |
X64877 |
| Entrez gene record: |
3080 |
| Pubmed identfication: |
1533657 7672821 |
| RefSeq identity: |
NM_005666 |
| Classification: |
Sushi domain containing Complement system |
| Havana BLAST/BLAT: |
OTTHUMG00000036518 |