| Also known as: |
PAG |
| Other names: |
Csk-binding protein, Csk-binding protein, Phosphoprotein associated with glycosphingolipid-enriched microdomains 1, Transmembrane adapter protein PAG, Transmembrane phosphoprotein Cbp, phosphoprotein associated with glycosphingolipid microdomains 1, phosphoprotein associated with glycosphingolipid-enriched microdomains 1, transmembrane adapter protein PAG, transmembrane adaptor protein PAG, transmembrane phosphoprotein Cbp, phosphoprotein associated with glycosphingolipid-enriched microdomains 1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
PAG |
| Other gene names: |
CBP, CBP, PAG, PAG, PAG1, PAG1 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2a |
| Clone: |
MEM-255 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
PAG acts not only acts as a 'co-factor' for relocating csk to substrate rich microdomains, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, _x000D_The transmission of signals along the various pathways within this cascade requires the phosphorylation of various substrates, _x000D__x000D_Evidence has shown that by binding to the SH2 domain of the PTK csk, _x000D__x000D_The engagement of immunoreceptors with natural ligands or antibodies is the initiating factor in a long line of events down a cytosolic signaling cascade, _x000D_an epitope (aa 235-280) located in the cytoplasmic domain of csk-binding protein (Cbp), a major negative regulator of src-family kinases, but also increases the affinity of csk for src-family kinases, by members of the src and syk families of protein tyrosine kinases (PTKs), through the formation of PAG-csk complexes, which localizes in membrane lipid rafts, PAG This item specifically recognizes the transmembrane adaptor protein known as Protein Associated with Glycosphingolipid-enriched microdomains (PAG) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, Ig concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Western Blot (WB) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
PAG |
| Short name: |
MOUSE Anti-HUMAN PAG Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens PAG (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Identity: |
30043 |
| Gene: |
PAG1 |
More about : PAG1 |
| Long gene name: |
phosphoprotein membrane anchor with glycosphingolipid microdomains 1 |
| Synonyms gene name: |
phosphoprotein associated with glycosphingolipid microdomains 1 |
| Synonyms: |
PAG CBP |
| Synonyms name: |
Csk-binding protein transmembrane adaptor protein PAG |
| Locus: |
8q21, 13 |
| Discovery year: |
2005-04-25 |
| GenBank acession: |
AF240634 |
| Entrez gene record: |
55824 |
| Pubmed identfication: |
10790433 |
| RefSeq identity: |
NM_018440 |
| Havana BLAST/BLAT: |
OTTHUMG00000164592 |