| known also as: |
Anti-RABBIT ANTI HUMAN CD274 |
| known also as: |
RABBIT ANTI HUMAN CD274 |
| known also as: |
Lapin ANTI Homo sapiens CD274 |
| known also as: |
CD274 |
| Other names: |
B7 homolog 1, B7 homolog 1, CD274 antigen, CD274 molecule, PDCD1 ligand 1, Programmed cell death 1 ligand 1, programmed cell death 1 ligand 1, programmed death ligand 1, programmed cell death 1 ligand 1 isoform b |
| Gene name: |
CD274 |
| Other gene names: |
B7-H, B7-H1, B7H1, B7H1, CD274, PD-L1, PD-L1, PDCD1 ligand 1, PDCD1L1, PDCD1L1, PDCD1LG1, PDCD1LG1, PDL1, PDL1, Programmed death ligand 1, CD274 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
B-cells, CD274 has also been shown to co-stimulate early T cell priming and differentiation, CD274 inhibits proliferation of activated T cells via ligation to the co-inhibitory molecule CD279 (programmed death-1, CD274 is expressed constitutively on macrophages and dendritic cells, PD-1) leading to the secretion of the regulatory cytokine interleukin-10, _x000D__x000D_CD274 is reported to possess dual functions, _x000D__x000D_Deregulated CD274 function has been reported in chronic viral and intracellular bacterial infection, a cell surface glycoprotein which is a member of the B7 family of co-stimulatory molecules, also known as B7-H1 and PD-1L, and is induced on activated T-cells, as well as in many autoimmune diseases and cancers, beta and gamma, endothelial cells and epithelial cells in response to Interferons alpha, inhibition of activated effector T cells and co-stimulation of naï, CD274 This item detects CD274, ve T cells |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Western Blot (WB), Immunohistology - Paraffin (IHC) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Gene target: |
CD274 |
| Short name: |
Anti-HUMAN CD274 |
| Alternative name: |
sapiens CD274 molecule, antibody to-H |
| Alternative to gene target: |
CD274 and IDBG-47487 and ENSG00000120217 and 29126, Cd274 and IDBG-157249 and ENSMUSG00000016496 and 60533, Cell surfaces, PD-L1 and IDBG-631351 and ENSBTAG00000000095 and 533834, protein binding, this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0006955 and immune response and biological process this GO :0007165 and signal transduction and biological process this GO :0007166 and cell surface receptor signaling pathway and biological process this GO :0009897 and external side of plasma membrane and cellular component this GO :0012505 and endomembrane system and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0031295 and T cell costimulation and biological process this GO :0042102 and positive regulation of T cell proliferation and biological process this GO :0042130 and negative regulation of T cell proliferation and biological process this GO :0045087 and innate immune response and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :2001181 and positive regulation of interleukin-10 secretion and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, CD274 molecule |
| Identity: |
17635 |
| Gene: |
CD274 |
More about : CD274 |
| Long gene name: |
CD274 molecule |
| Synonyms gene: |
PDCD1LG1 |
| Synonyms gene name: |
programmed cell death 1 ligand 1 CD274 antigen |
| Synonyms: |
B7-H B7H1 PD-L1 PDL1 B7-H1 |
| Synonyms name: |
B7 homolog 1 |
| Locus: |
9p24, 1 |
| Discovery year: |
2003-11-13 |
| GenBank acession: |
AF177937 |
| Entrez gene record: |
29126 |
| Pubmed identfication: |
11015443 10581077 |
| RefSeq identity: |
NM_014143 |
| Classification: |
Endogenous ligands C2-set domain containing CD molecules V-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000019503 |