| Also known as: |
CD46 |
| Other names: |
CD46 antigen, CD46 molecule, Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen, antigen identified by monoclonal antibody TRA-2-10, complement membrane cofactor protein, complement regulatory protein, complement regulatory protein, measles virus receptor, membrane cofactor protein, membrane cofactor protein (CD46, trophoblast leucocyte common antigen, trophoblast leukocyte common antigen, trophoblast-lymphocyte cross-reactive antigen, trophoblast-lymphocyte cross-reactive antigen), membrane cofactor protein isoform 1 |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
CD46 |
| Other gene names: |
AHUS2, CD46, MCP, MCP, MIC10, MIC10, TLX, TRA2, 10, CD46 |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG1 |
| Clone: |
MEM-258 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
CD46 functions as an inhibitor of complement activation limiting the formation and activity of C3 convertases, CD46 is expressed by all nucleated cells, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, The molecule is also expressed by sperm and may be important in the process of fertilisation, This particular antibody might cross react with speacies outside of the listed ones, a broadly expressed glycoprotein also known as membrane co-factor protein (MCP), often as multiple isoforms on the same cells, CD46 This item recognises the human CD46 cell surface antigen |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 1 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, Storage in frost-free freezers is not recommended, the antibody should be stored undiluted, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Flow Cytometry (FACS), Functional Assay (FA), Immunoprecipitation (IP), Western Blot (WB), Immunofluorescence (IF) |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Gene target: |
CD46 |
| Short name: |
MOUSE Anti-HUMAN CD46 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
complement regulatory protein (Antibody to), sapiens CD46 molecule, MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
AHUS2 and MCP and MIC10 and TLX and TRA2, BT, CD46 and IDBG-106372 and ENSG00000117335 and 4179, Cd46 and IDBG-209330 and ENSMUSG00000016493 and 17221, Cell surfaces, cadherin binding, classical pathway and biological process this GO :0007338 and single fertilization and biological process this GO :0008593 and regulation of Notch signaling pathway and biological process this GO :0009986 and cell surface and cellular component this GO :0010628 and positive regulation of gene expression and biological process this GO :0010629 and negative regulation of gene expression and biological process this GO :0016032 and viral process and biological process this GO :0030449 and regulation of complement activation and biological process this GO :0032613 and interleukin-10 production and biological process this GO :0032733 and positive regulation of interleukin-10 production and biological process this GO :0035581 and sequestering of extracellular ligand from receptor and biological process this GO :0042102 and positive regulation of T cell proliferation and biological process this GO :0043382 and positive regulation of memory T cell differentiation and biological process this GO :0045087 and innate immune response and biological process this GO :0045296 and cadherin binding and molecular function this GO :0045591 and positive regulation of regulatory T cell differentiation and biological process this GO :0070062 and extracellular vesicular exosome and cellular component this GO :0071636 and positive regulation of transforming growth factor beta production and biological process, complement regulatory protein, this GO :0002079 and inner acrosomal membrane and cellular component this GO :0002250 and adaptive immune response and biological process this GO :0002456 and T cell mediated immunity and biological process this GO :0004872 and receptor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0005887 and integral component of plasma membrane and cellular component this GO :0006958 and complement activation, this GO :0004872 : receptor activity, this GO :0004872 : receptor activity and also this GO :0005515 : protein binding and also this GO :0045296 : cadherin binding, this GO :0005515 : protein binding, this GO :0045296 : cadherin binding, 10, 68611 and IDBG-638462 and ENSBTAG00000005397 and 280851, CD46 molecule |
| Identity: |
6953 |
| Gene: |
CD46 |
More about : CD46 |
| Long gene name: |
CD46 molecule |
| Synonyms gene: |
MIC10 MCP |
| Synonyms gene name: |
antigen identified by monoclonal antibody TRA-2-10 membrane cofactor protein (CD46, complement regulatory protein , complement regulatory protein CD46 molecule, trophoblast-lymphocyte cross-reactive antigen) CD46 antigen |
| Synonyms: |
TRA2, 10 MGC26544 TLX |
| Locus: |
1q32, 2 |
| Discovery year: |
1988-08-31 |
| GenBank acession: |
BC030594 |
| Entrez gene record: |
4179 |
| Pubmed identfication: |
7929741 |
| RefSeq identity: |
NM_172361 |
| Classification: |
Sushi domain containing Complement system CD molecules |
| Havana BLAST/BLAT: |
OTTHUMG00000036397 |
| Locus Specific Databases: |
LRG_155 |