| known also as: |
Anti-RABBIT ANTI PRESENILIN-1 |
| known also as: |
RABBIT ANTI PRESENILIN-1 |
| known also as: |
Lapin ANTI PRESENILIN-1 |
| known also as: |
PRESENILIN-1 |
| Other names: |
Presenilin-1, Protein S182, presenilin 1, presenilin-1, presenilin-1 isoform I-467 |
| Other gene names: |
AD3, AD3, FAD, PS-1, PS-1, PS1, PS1, PS1-CTF12, PSEN1, PSNL1, S182, PSEN1 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
Cleavage of these proteins is a key step in signalling from several cell-surface receptors and is believed to be required for the generation of neurotoxic amyloid peptides that are central in the development of Alzheimer's disease, Nicastrin and APH-1, Presenilin-1, _x000D__x000D_Presenilin-1 was originally identified as a marker of susceptibility for familial early onset Alzheimer's disease type 3 (AD3), _x000D__x000D_Research indicates that at least 6 isoforms of Presenilin-1 exist, _x000D__x000D_This item is specific for Presenilin-1 and shows no cross reactivity with Presenilin-2, a 52, a membrane-bound aspartyl protease that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP, along with PEN2, forms the gamma-secretase protein complex, liver, spleen and lymph nodes, 7 kDa membrane protein expressed in a wide range of tissues including various regions of the brain, PRESENILIN-1 This item recognises human Presenilin-1 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Immunohistology - Paraffin (IHC), Western Blot (WB) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target: |
PRESENILIN-1 |
| Short name: |
Anti-PRESENILIN-1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
antibody to-PRESENILIN-1 (Antibody to) |
| Alternative technique: |
antibodies |