| known also as: |
Anti-RABBIT ANTI HUMAN PRESENILIN-1 (LOOP) |
| known also as: |
RABBIT ANTI HUMAN PRESENILIN-1 (LOOP) |
| known also as: |
Lapin ANTI Homo sapiens PRESENILIN-1 (LOOP) |
| known also as: |
PRESENILIN-1 |
| Other names: |
Presenilin-1, Protein S182, presenilin 1, presenilin-1, presenilin-1 isoform I-467 |
| Other gene names: |
AD3, AD3, FAD, PS-1, PS-1, PS1, PS1, PS1-CTF12, PSEN1, PSNL1, S182, PSEN1 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
PSEN1 is an essential component of the gamma-secretase complex, PSEN2, Pen-2 (PEN2), This endoprotease complex plays a vital role in the evolutionarily conserved Notch signaling pathway, _x000D__x000D_Mutations of presenilin-1 are associated with early onset Alzheimer's disease, along with APH-1 (APH-1A or APH-1B), an integral membrane protein that is widely expressed, and nicastrin (NCSTN), by catalyzing the intramembrane S3 cleavage of ligand-activated Notch receptor proteins (Notch1-4), especially in brain tissue, resulting in the generation and release of an activated NICD fragment, which then translocates to the nucleus and activates the transcription of downstream effector genes, PRESENILIN-1 This item recognises presenilin-1 (PSEN1) |
| Form/Appearance: |
Serum (Serum - liquid) |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Immunoprecipitation (IP), Western Blot (WB), Immunohistology - Frozen (IHC) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target: |
PRESENILIN-1 (LOOP) |
| Short name: |
Anti-HUMAN PRESENILIN-1 (LOOP) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
sapiens PRESENILIN-1 (LOOP) (Antibody to), antibody to-H |
| Alternative technique: |
antibodies |