| known also as: |
Anti-RABBIT ANTI MOUSE MDM2 |
| known also as: |
RABBIT ANTI Murine MDM2 |
| known also as: |
Lapin ANTI Mus musculus MDM2 |
| known also as: |
MDM2 |
| Other names: |
Double minute 2 protein, E3 ubiquitin-protein ligase Mdm2, E3 ubiquitin-protein ligase Mdm2, Oncoprotein Mdm2, double minute 2 protein, oncoprotein Mdm2, p53-binding protein Mdm2, p53-binding protein Mdm2, transformed mouse 3T3 cell double minute 2, E3 ubiquitin-protein ligase Mdm2 |
| Gene name: |
MDM2 |
| Other gene names: |
1700007J15Rik, AA415488, Mdm-2, Mdm2, N/A, Mdm2 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Mouse |
| Specificity and cross-reactivity: |
Mdm2 also interacts with the retinoblastoma (RB) protein and E2F-1, _x000D__x000D_Mdm2 activity is controlled by self-ubiquitination, a nuclear phosphoprotein that controls intracellular levels of the tumour suppressor protein p53 by ubiquitination and subsequent proteasomal degradation, however activation of the PI3K/PKB pathway leads to phosphorylation of Mdm2 at Ser185, to promote G1-S phase transition in the cell cycle, which stabilises the protein, MDM2 This item detects murine Mdm2 |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
IgG concentration 500ug/1000ul |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Western Blot (WB), ELISA (EIA) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target: |
MDM2 |
| Short name: |
Anti-MOUSE MDM2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
antibody to-MOUSE MDM2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6973 |
| Gene: |
MDM2 |
More about : MDM2 |
| Long gene name: |
MDM2 proto-oncogene |
| Synonyms gene name: |
E3 ubiquitin protein ligase , human homolog of, mouse double minute 2, p53 binding protein (mouse) Mdm2 p53 binding protein homolog (mouse) MDM2 proto-oncogene, p53-binding protein Mdm2, transformed 3T3 cell double minute 2 |
| Synonyms: |
HDM2 MGC5370 |
| Locus: |
12q15 |
| Discovery year: |
1993-12-10 |
| Entrez gene record: |
4193 |
| Pubmed identfication: |
1614537 16905769 |
| RefSeq identity: |
NM_006880 |
| Classification: |
Zinc fingers RANBP2-type |
| Havana BLAST/BLAT: |
OTTHUMG00000142827 |