| Also known as: |
MICA/MICB |
| Other names: |
HLA class I antigen, MHC class I chain-related protein A, MHC class I polypeptide-related sequence A, MHC class I polypeptide-related sequence A, MHC class I polypeptide-related sequence A, N/A, stress inducible class I homolog, MHC class I polypeptide-related sequence A isoform 1 (MICA*001) |
| Category: |
Antibodies |
| Subcategory: |
Mnoclonal antibodies |
| Gene name: |
MICA/MICB |
| Other gene names: |
MIC-A, MIC-A, MICA, PERB11, PERB11, 1, 1, MICA |
| Clonality: |
Monoclonal |
| Immunoglobulin isotype: |
IgG2a |
| Clone: |
6D4 |
| Host organism: |
Mouse (Mus musculus) |
| Species reactivity: |
Due to limited knowledge and inability for testing each and every species, the reactivity of the antibody may extend to other species which are not listed hereby, Human (Homo sapiens) |
| Specificity and cross-reactivity: |
CD8 T cells and gamma delta T cells, Clone 6D4 is reported to inhibit the cytotoxicity of NK cells stimulated by IFN alpha-treated dendritic cells, Expression may be induced to high surface levels by heat shock, MICA and MICB are ligands for NKG2D, MICA and MICB are stress inducible antigens, MICA is principally expressed on intestinal epithelium, Since it is not possible to test each and every species our knowledge on the corss reactivity of the antibodies is limited, This particular antibody might cross react with speacies outside of the listed ones, an activating receptor on most natural killer (NK) cells, and several epithelial tumours, and virus infection, oxidative stress, which are closely related and appear functionally indistinguishable, MICA/MICB This item is specific for nonclassical MHC class I chain A (MICA) and nonclassical MHC class I chain MICB (MICB) |
| Form/Appearance: |
Biotin (Purified IgG conjugated to Biotin - liquid) |
| Concentration: |
1 miligram per 1 mililiter, IgG concentration 0 |
| Storage and shipping: |
If there is a precipitate in the vial we recommend you to briefly microcentrifugate it prior to use, Repeated freeze - thaw cycles may denature the peptide chains of the antibody and therefore should be maximally avoided, Shelf Life: 18 months from date of dispatch, the antibody should be stored undiluted, Storage in frost-free freezers is not recommended, Store the antibody at +4 degrees Celsius for short-term storage and at -20 degrees Celsius for long-term |
| Tested applications:: |
Immunohistology - Frozen (IHC), Flow Cytometry (FACS) |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS mono they should be stored frozen at - 24° |
| Conjugation: |
Biotinylated |
| Gene target: |
MICA/MICB: |
| Short name: |
MOUSE Anti-HUMAN MICA/MICB: Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
Biotin |
| Alternative name: |
sapiens Major histocompabitility complex class I polypeptide-related sequence A/Major histocompabitility complex class I polypeptide-related sequence B:biotinilated (Antibody to), MOUSE antibody to-H |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cell surfaces, MHC class I polypeptide-related sequence B, MICA and IDBG-77578 and ENSG00000204520 and 100507436, MICB and IDBG-77697 and ENSG00000204516 and 4277, PERB11, Plasma membranes, natural killer cell lectin-like receptor binding, protein binding, this GO :0002429 and immune response-activating cell surface receptor signaling pathway and biological process this GO :0005515 and protein binding and molecular function this GO :0005886 and plasma membrane and cellular component this GO :0006955 and immune response and biological process this GO :0006979 and response to oxidative stress and biological process this GO :0009408 and response to heat and biological process this GO :0009986 and cell surface and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0016032 and viral process and biological process this GO :0019835 and cytolysis and biological process this GO :0019882 and antigen processing and presentation and biological process this GO :0032526 and response to retinoic acid and biological process this GO :0046629 and gamma-delta T cell activation and biological process this GO :0046703 and natural killer cell lectin-like receptor binding and molecular function this GO :0050689 and negative regulation of defense response to virus by host and biological process this GO :0050776 and regulation of immune response and biological process, this GO :0005515 and protein binding and molecular function this GO :0006955 and immune response and biological process this GO :0016020 and membrane and cellular component this GO :0016021 and integral component of membrane and cellular component this GO :0019882 and antigen processing and presentation and biological process this GO :0045087 and innate immune response and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0046703 : natural killer cell lectin-like receptor binding, this GO :0046703 : natural killer cell lectin-like receptor binding, 2, MHC class I polypeptide-related sequence A |
| Identity: |
7090 |
| Gene: |
MICA |
More about : MICA |
| Long gene name: |
MHC class I polypeptide-related sequence A |
| Synonyms: |
PERB11, 1 |
| Locus: |
6p21, 33 |
| Discovery year: |
1994-05-16 |
| GenBank acession: |
L14848 |
| Entrez gene record: |
100507436 |
| Pubmed identfication: |
8022771 |
| RefSeq identity: |
NM_001177519 |
| Classification: |
C1-set domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000031073 |
| Locus Specific Databases: |
IMGT/HLA Database |