| known also as: |
Anti-RABBIT ANTI HUMAN BLM |
| known also as: |
RABBIT ANTI HUMAN BLM |
| known also as: |
Lapin ANTI Homo sapiens BLM |
| known also as: |
BLM |
| Other names: |
Bloom syndrome, Bloom syndrome protein, Bloom syndrome protein, DNA helicase, DNA helicase, RecQ helicase-like, RecQ protein-like 3, RecQ-like type 2, RecQ-like type 2, RecQ2, recQ protein-like 3, Bloom syndrome protein |
| Gene name: |
BLM |
| Other gene names: |
BLM, BS, RECQ2, RECQ2, RECQL2, RECQL3, RECQL3, RecQ2, BLM |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
BLM is a member of the RecQ family of helicases, _x000D__x000D_BLM has been implicated in Bloom Syndrome, a DNA binding protein with helicase activity, an autosomal recessive diseases characterised by chromosome fragility and cancer proneness, which has an important role in maintaining genome stability by suppressing inappropriate recombination, BLM This item is specific for human Bloom Syndrome (BLM) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0 mg/ml, IgG concentration 1 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Western Blot (WB), Immunoprecipitation (IP) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Gene target: |
BLM |
| Short name: |
Anti-HUMAN BLM |
| Alternative name: |
RecQ helicase-like, sapiens Bloom syndrome, antibody to-H |
| Alternative to gene target: |
BLM and IDBG-30365 and ENSG00000197299 and 641, BLM and IDBG-629490 and ENSBTAG00000020301 and 534148, BS and RECQ2 and RECQL2 and RECQL3, Blm and IDBG-195418 and ENSMUSG00000030528 and 12144, DNA-templated and biological process this GO :0045910 and negative regulation of DNA recombination and biological process this GO :0045950 and negative regulation of mitotic recombination and biological process this GO :0046632 and alpha-beta T cell differentiation and biological process this GO :0046641 and positive regulation of alpha-beta T cell proliferation and biological process this GO :0048478 and replication fork protection and biological process this GO :0051098 and regulation of binding and biological process this GO :0051259 and protein oli this GO merization and biological process this GO :0051276 and chromosome organization and biological process this GO :0051782 and negative regulation of cell division and biological process this GO :0051880 and G-quadruplex DNA binding and molecular function this GO :0070244 and negative regulation of thymocyte apoptotic process and biological process this GO :0071479 and cellular response to ionizing radiation and biological process this GO :0072711 and cellular response to hydroxyurea and biological process this GO :0072757 and cellular response to camptothecin and biological process, RecQ helicase-like, acting on acid anhydrides, acting on acid anhydrides, acting on acid anhydrides, hydrolase activity, in phosphorus-containing anhydrides, in phosphorus-containing anhydrides and also this GO :0016887 : ATPase activity and also this GO :0036310 : annealing helicase activity and also this GO :0043140 : ATP-dependent 3'-5' DNA helicase activity and also this GO :0051880 : G-quadruplex DNA binding, in phosphorus-containing anhydrides and molecular function this GO :0016887 and ATPase activity and molecular function this GO :0031297 and replication fork processing and biological process this GO :0031572 and G2 DNA damage checkpoint and biological process this GO :0032508 and DNA duplex unwinding and biological process this GO :0036310 and annealing helicase activity and molecular function this GO :0043140 and ATP-dependent 3'-5' DNA helicase activity and molecular function this GO :0044237 and cellular metabolic process and biological process this GO :0045120 and pronucleus and cellular component this GO :0045893 and positive regulation of transcription, nuclei, telomeric region and cellular component this GO :0000800 and lateral element and cellular component this GO :0001673 and male germ cell nucleus and cellular component this GO :0002039 and p53 binding and molecular function this GO :0003676 and nucleic acid binding and molecular function this GO :0003677 and DNA binding and molecular function this GO :0003697 and single-stranded DNA binding and molecular function this GO :0003824 and catalytic activity and molecular function this GO :0004003 and ATP-dependent DNA helicase activity and molecular function this GO :0004386 and helicase activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005524 and ATP binding and molecular function this GO :0005622 and intracellular and cellular component this GO :0005634 and nucleus and cellular component this GO :0005657 and replication fork and cellular component this GO :0005730 and nucleolus and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0006200 and ATP catabolic process and biological process this GO :0006260 and DNA replication and biological process this GO :0006281 and DNA repair and biological process this GO :0006310 and DNA recombination and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0008026 and ATP-dependent helicase activity and molecular function this GO :0009378 and four-way junction helicase activity and molecular function this GO :0010165 and response to X-ray and biological process this GO :0016363 and nuclear matrix and cellular component this GO :0016605 and PML body and cellular component this GO :0016818 and hydrolase activity, this GO :0000079 and regulation of cyclin-dependent protein serine/threonine kinase activity and biological process this GO :0000085 and mitotic G2 phase and biological process this GO :0000166 and nucleotide binding and molecular function this GO :0000228 and nuclear chromosome and cellular component this GO :0000405 and bubble DNA binding and molecular function this GO :0000723 and telomere maintenance and biological process this GO :0000724 and double-strand break repair via homolo this GO us recombination and biological process this GO :0000729 and DNA double-strand break processing and biological process this GO :0000733 and DNA strand renaturation and biological process this GO :0000781 and chromosome, this GO :0000166 : nucleotide binding, this GO :0000166 : nucleotide binding and also this GO :0000405 : bubble DNA binding and also this GO :0002039 : p53 binding and also this GO :0003676 : nucleic acid binding and also this GO :0003677 : DNA binding and also this GO :0003697 : single-stranded DNA binding and also this GO :0003824 : catalytic activity and also this GO :0004003 : ATP-dependent DNA helicase activity and also this GO :0004386 : helicase activity and also this GO :0005515 : protein binding and also this GO :0005524 : ATP binding and also this GO :0008026 : ATP-dependent helicase activity and also this GO :0009378 : four-way junction helicase activity and also this GO :0016818 : hydrolase activity, this GO :0000405 : bubble DNA binding, this GO :0002039 : p53 binding, this GO :0003676 : nucleic acid binding, this GO :0003677 : DNA binding, this GO :0003697 : single-stranded DNA binding, this GO :0003824 : catalytic activity, this GO :0004003 : ATP-dependent DNA helicase activity, this GO :0004386 : helicase activity, this GO :0005515 : protein binding, this GO :0005524 : ATP binding, this GO :0008026 : ATP-dependent helicase activity, this GO :0009378 : four-way junction helicase activity, this GO :0016818 : hydrolase activity, this GO :0016887 : ATPase activity, this GO :0036310 : annealing helicase activity, this GO :0043140 : ATP-dependent 3'-5' DNA helicase activity, this GO :0051880 : G-quadruplex DNA binding, Bloom syndrome |
| Identity: |
1058 |
| Gene: |
BLM |
More about : BLM |
| Long gene name: |
Bloom syndrome RecQ like helicase |
| Synonyms gene name: |
Bloom syndrome |
| Synonyms: |
BS RECQL3 RECQ2 |
| Locus: |
15q26, 1 |
| Discovery year: |
1992-11-06 |
| GenBank acession: |
U39817 |
| Entrez gene record: |
641 |
| Pubmed identfication: |
9388193 |
| Classification: |
RecQ like helicases |
| Havana BLAST/BLAT: |
OTTHUMG00000149834 |
| Locus Specific Databases: |
BLMbase: Mutation registry for Bloom Syndrome LRG_20 |