| known also as: |
Anti-RABBIT ANTI HUMAN CNTF |
| known also as: |
RABBIT ANTI HUMAN CNTF |
| known also as: |
Lapin ANTI Homo sapiens CNTF |
| known also as: |
CNTF |
| Other names: |
Ciliary neurotrophic factor, N/A, ciliary neurotrophic factor, ciliary neurotrophic factor, ciliary neurotrophic factor |
| Gene name: |
CNTF |
| Other gene names: |
CNTF, CNTF, HCNTF, CNTF |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
CNTF mainly signals through binding to a receptor complex consisting of a CNTFRa subunit, a 200 amino acid homodimeric neurotrophic and differentiation factor of the CNTF family, but CNTF has also been shown to bind to the receptor for interleukin-6 (IL-6R), but also affects other target tissues, glial cells, gp130 and LIFR, hepatocytes and embryonic stem cells, including skeletal muscle, resulting ultimately in the activation of JAK/STAT signalling pathway, two beta components, which supports the survival and differentiation of several motor neuron types within the nervous system, CNTF This product recognises human CNTF (ciliary neurotrophic factor) |
| Form/Appearance: |
Purified (Purified IgG - lyophilised) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
After reconstitution For optimal long term storage, Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 12 months from date of reconstitution, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, productone should be kept at -20 degrees Celsius, productone should be stored undiluted, Prior to reconstitution store at +Store productone at +4 degrees Celsius |
| Tested for:: |
ELISA (EIA), Functional Assay (FA), Immunohistology - Paraffin (IHC), Western Blot (WB) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Gene target: |
CNTF |
| Short name: |
Anti-HUMAN CNTF |
| Alternative name: |
sapiens ciliary neurotrophic factor, antibody to-H |
| Alternative to gene target: |
CNTF and IDBG-409278 and ENSG00000242689 and 1270, CNTF and IDBG-637978 and ENSBTAG00000003624 and 100848228, Cntf and IDBG-254935 and ENSMUSG00000079415 and 12803, Extracellular, HCNTF, growth factor activity, this GO :0005127 and ciliary neurotrophic factor receptor binding and molecular function this GO :0005138 and interleukin-6 receptor binding and molecular function this GO :0005615 and extracellular space and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0007165 and signal transduction and biological process this GO :0008083 and growth factor activity and molecular function this GO :0008284 and positive regulation of cell proliferation and biological process this GO :0040007 and growth and biological process this GO :0042517 and positive regulation of tyrosine phosphorylation of Stat3 protein and biological process this GO :0043524 and negative regulation of neuron apoptotic process and biological process this GO :0046533 and negative regulation of photoreceptor cell differentiation and biological process this GO :0046668 and regulation of retinal cell programmed cell death and biological process this GO :0048644 and muscle organ morphogenesis and biological process this GO :0048666 and neuron development and biological process this GO :0070120 and ciliary neurotrophic factor-mediated signaling pathway and biological process this GO :0097058 and CRLF-CLCF1 complex and cellular component, this GO :0005127 : ciliary neurotrophic factor receptor binding, this GO :0005127 : ciliary neurotrophic factor receptor binding and also this GO :0005138 : interleukin-6 receptor binding and also this GO :0008083 : growth factor activity, this GO :0005138 : interleukin-6 receptor binding, this GO :0008083 : growth factor activity, ciliary neurotrophic factor |
| Identity: |
2169 |
| Gene: |
CNTF |
More about : CNTF |
| Long gene name: |
ciliary neurotrophic factor |
| Synonyms: |
HCNTF |
| Locus: |
11q12, 1 |
| Discovery year: |
1991-01-07 |
| GenBank acession: |
BC068030 |
| Entrez gene record: |
1270 |
| Pubmed identfication: |
1840538 1714745 |
| RefSeq identity: |
NM_000614 |
| Classification: |
Interleukin 6 cytokine family |
| Havana BLAST/BLAT: |
OTTHUMG00000137476 |
| Locus Specific Databases: |
ALSOD, the Amyotrophic Lateral Sclerosis Online Genetic Database |