| known also as: |
Anti-RABBIT ANTI IRE1p (C-TERMINAL) |
| known also as: |
RABBIT ANTI IRE1p (C-TERMINAL) |
| known also as: |
Lapin ANTI IRE1p (C-TERMINAL) |
| known also as: |
IRE1p |
| Other names: |
ER to nucleus signalling 1, Endoplasmic reticulum-to-nucleus signaling 1, Inositol-requiring protein 1, Ire1-alpha, Serine/threonine-protein kinase/endoribonuclease IRE1, endoplasmic reticulum to nucleus signaling 1, endoplasmic reticulum-to-nucleus signaling 1, hIRE1p, inositol-requiring 1, inositol-requiring enzyme 1, inositol-requiring protein 1, ire1-alpha, serine/threonine-protein kinase/endoribonuclease IRE1, serine/threonine-protein kinase/endoribonuclease IRE1 |
| Gene name: |
IRE1p |
| Other gene names: |
ERN1, IRE1, IRE1, IRE1P, IRE1a, IRE1a, hIRE1p, hIRE1p, ERN1 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
At times of ER stress, IRE1p becomes dissociated from the chaperones, In the mammalian genome, Ire1alpha is expressed in all cells and tissues, Ire1beta expression is primarily restricted to intestinal epithelial cells, It is an endoplasmic reticulum (ER) transmembrane protein, a 108kDa serine-threonine kinase/endoribonuclease also known as ERN1, due to accumulation of unfolded proteins, normally bound to the ER molecular chaperones GRP78 and GRP94, there are two homologs Ire1alpha and Ire1beta, which allows it to activate the un-folded protein transcriptional response (UPR), IRE1p This item recognises inositol-requiring kinase 1 precursor (IRE1p) |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Western Blot (WB), Immunohistology - Frozen (IHC) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Gene target: |
IRE1p |
| Short name: |
Anti-IRE1p (C-TERMINAL) |
| Alternative name: |
antibody to-IRE1p (C-TERMINAL) |
| Identity: |
3449 |
| Gene: |
ERN1 |
More about : ERN1 |
| Long gene name: |
endoplasmic reticulum to nucleus signaling 1 |
| Synonyms gene name: |
ER to nucleus signalling 1 |
| Synonyms: |
IRE1 IRE1P |
| Synonyms name: |
inositol-requiring enzyme 1 Serine/threonine-protein kinase/endoribonuclease IRE1 |
| Locus: |
17q23, 3 |
| Discovery year: |
1998-08-06 |
| GenBank acession: |
AF059198 |
| Entrez gene record: |
2081 |
| Pubmed identfication: |
9637683 |
| RefSeq identity: |
NM_001433 |
| Havana BLAST/BLAT: |
OTTHUMG00000178879 |