| known also as: |
Anti-RABBIT ANTI TSC1 |
| known also as: |
RABBIT ANTI TSC1 |
| known also as: |
Lapin ANTI TSC1 |
| known also as: |
TSC1 |
| Other names: |
Hamartin, Tuberous sclerosis 1 protein, hamartin, tuberous sclerosis 1, tuberous sclerosis 1 protein, tumor suppressor, hamartin isoform 1 |
| Gene name: |
TSC1 |
| Other gene names: |
KIAA0243, LAM, TSC, TSC, TSC1, TSC1 |
| Category: |
Antibodies |
| Clonality: |
Polyclonal |
| Immunoglobulin isotype: |
Polyclonal IgG |
| Clone: |
Polyclonal antibody |
| Host organism: |
Rabbit |
| Species reactivity: |
Human |
| Specificity and cross-reactivity: |
Furthermore the TOR activator protein Rheb has been identified as a target of TSC1-TSC2 complexes, Mutation within the TSC1 gene is responsible for Tuberous sclerosis (TSC), Negative regulation of TOR activity occurs following the over-expression of the TSC1 and TSC2 gene products, These act by suppressing the phosphorylation of eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and ribosomal protein S6 kinase (S6K), Tumour sclerosis complex 1 (TSC1), _x000D_Many proteins have been shown to play a role in the regulation of the serine/threonine kinase known as target of rapamycin (TOR), _x000D__x000D_This item has been reported as suitable for use in IHC on mouse EL4 cell cytospins at 2ug/ml, a central component in a complex signaling pathway which controls cell proliferation and cell cycle progression, a condition also induced by mutation of the Tumour sclerosis complex 2 (TSC2) gene, an autosomal dominant genetic disorder associated with the development of benign tumors (hamartomas), downstream targets of TOR involved in mRNA translation, hamartin and tuberin, TSC1 This item recognises an epitope within the internal region of the 130kDa tumour suppressor protein, _x000D_ |
| Form/Appearance: |
Purified (Purified IgG - liquid) |
| Concentration: |
0mg/ml, IgG concentration 1 |
| Storage and shipping: |
Avoid repeated freezing and thawing as this may denature the antibody, Shelf Life: 18 months from date of dispatch, Should productone contain a precipitate we recommend microcentrifugation before use, Storage in frost-free freezers is not recommended, if preferred, or productone should be stored at -20 degrees Celsius, productone should be stored undiluted, Store at +Store productone at +4 degrees Celsius |
| Tested for:: |
Western Blot (WB), Immunohistology - Frozen (IHC) |
| Description: |
Polyclonal antibodies generally are more stable and retain their reactivity under unfavorable conditions, Polyclonal antibodies have series of advantages - larger batches can be supplied at a time, Properly used, To obtain more detailed information on productone, please, refer to the full product datasheet, the time needed for production is considerably shorter, they are inexpensive to manufacture and respectively to buy, this antibody will ensure excellent and reproducible results with guaranteed success for the applications that it is tested in, productone is a polyclonal antibody of high purity and binding affinity for the antigen that it is risen against |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, avoid cycles of freezing and thawing, please, In order to retain the quality and the affinity of productone unchanged |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by MBS Polyclonals_1 they should be stored frozen at - 24° |
| Gene target: |
TSC1 |
| Short name: |
Anti-TSC1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
antibody to-TSC1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
12362 |
| Gene: |
TSC1 |
More about : TSC1 |
| Long gene name: |
tuberous sclerosis 1 |
| Synonyms gene: |
TSC |
| Synonyms: |
KIAA0243 LAM hamartin |
| Locus: |
9q34 |
| Discovery year: |
1986-01-01 |
| GenBank acession: |
AF013168 |
| Pubmed identfication: |
9242607 10806479 |
| Havana BLAST/BLAT: |
OTTHUMG00000020844 |
| Locus Specific Databases: |
TSC Mutation Database Tuberous sclerosis database LRG_486 |