| Long name: |
Biotin Conjugated, MYBPC3 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
MYBPC3 |
| Specificity: |
This is a highly specific antibody against MYBPC3 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human MYBPC3 |
| Gene ID number: |
4607 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
It is found in the crossbridge-bearing zone (C region) of A bands in vertebrate striated muscle, MHC and native thin filaments, MYBPC3 binds F-Actin, Mutations in the MYBPC3 gene lead mainly to truncation of the protein, Regulatory phosphorylation of MYBPC3 by cAMP-dependent protein kinase (PKA) upon adrenergic stimulation may be linked to modulation of cardiac contraction, The MYBPC3 gene maps to chromosome 11p11, a heart disorder characterized by ventricular hypertrophy, and modifies the activity of Actin-activated myosin ATPase, which often involves the interventricular septum and is usually asymmetric, which results in one cause of familial hypertrophic cardiomyopathy type 4 (CMH4), 2, MYBPC3 encodes the cardiac isoform of the thick-filament myosin-binding protein C |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
MYBP-C FHC |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
MYBPC3 Conjugated |
| Short name: |
Conjugated, MYBPC3 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, cardiac (Antibody to), myosin binding protein C |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CMD1MM and CMH4 and FHC and LVNC10 and MYBP-C, Cytoplasm, MYBPC3 and IDBG-43206 and ENSG00000134571 and 4607, MYBPC3 and IDBG-637371 and ENSBTAG00000021707 and 767614, Mybpc3 and IDBG-190220 and ENSMUSG00000002100 and 17868, cardiac, metal ion binding, this GO :0001671 and ATPase activator activity and molecular function this GO :0002027 and regulation of heart rate and biological process this GO :0003007 and heart morphogenesis and biological process this GO :0003779 and actin binding and molecular function this GO :0005515 and protein binding and molecular function this GO :0005829 and cytosol and cellular component this GO :0005863 and striated muscle myosin thick filament and cellular component this GO :0006936 and muscle contraction and biological process this GO :0006942 and regulation of striated muscle contraction and biological process this GO :0007155 and cell adhesion and biological process this GO :0008016 and regulation of heart contraction and biological process this GO :0008307 and structural constituent of muscle and molecular function this GO :0014705 and C zone and cellular component this GO :0017022 and myosin binding and molecular function this GO :0030016 and myofibril and cellular component this GO :0030017 and sarcomere and cellular component this GO :0030049 and muscle filament sliding and biological process this GO :0031034 and myosin filament assembly and biological process this GO :0031432 and titin binding and molecular function this GO :0031672 and A band and cellular component this GO :0032036 and myosin heavy chain binding and molecular function this GO :0032781 and positive regulation of ATPase activity and biological process this GO :0032971 and regulation of muscle filament sliding and biological process this GO :0042802 and identical protein binding and molecular function this GO :0045214 and sarcomere organization and biological process this GO :0046872 and metal ion binding and molecular function this GO :0055010 and ventricular cardiac muscle tissue morphogenesis and biological process this GO :0060048 and cardiac muscle contraction and biological process, this GO :0001671 : ATPase activator activity, this GO :0001671 : ATPase activator activity and also this GO :0003779 : actin binding and also this GO :0005515 : protein binding and also this GO :0008307 : structural constituent of muscle and also this GO :0017022 : myosin binding and also this GO :0031432 : titin binding and also this GO :0032036 : myosin heavy chain binding and also this GO :0042802 : identical protein binding and also this GO :0046872 : metal ion binding, this GO :0003779 : actin binding, this GO :0005515 : protein binding, this GO :0008307 : structural constituent of muscle, this GO :0017022 : myosin binding, this GO :0031432 : titin binding, this GO :0032036 : myosin heavy chain binding, this GO :0042802 : identical protein binding, this GO :0046872 : metal ion binding, myosin binding protein C |
| Identity: |
7551 |
| Gene: |
MYBPC3 |
More about : MYBPC3 |
| Long gene name: |
cardiac , myosin binding protein C |
| Synonyms gene: |
CMH4 |
| Synonyms gene name: |
cardiac , myosin-binding protein C |
| Locus: |
11p11, 2 |
| Discovery year: |
1995-05-30 |
| GenBank acession: |
X84075 |
| Entrez gene record: |
4607 |
| Pubmed identfication: |
7744002 8358441 |
| Classification: |
I-set domain containing Myosin binding proteins Fibronectin type III domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000166986 |
| Locus Specific Databases: |
FHC Mutation Database LRG_386 |