| Long name: |
FITC Conjugated, INTS3 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
INTS3 |
| Specificity: |
This is a highly specific antibody against INTS3 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
960-998/1043 |
| Subcellular location: |
Nucleus |
| Source: |
KLH conjugated synthetic peptide derived from human INTS3 |
| Gene ID number: |
65123 |
| Swiss Prot: |
Q68E01 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Component of the SOSS complex, In the SOSS complex, The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes, The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing, The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites, recombinational repair and maintenance of genomic stability, Component of the Integrator complex |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
FLJ21919 INT3 SOSS-A |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
INTS3 Conjugated |
| Short name: |
FITC Conjugated, INTS3 Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, INTS3 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
26153 |
| Gene: |
INTS3 |
More about : INTS3 |
| Long gene name: |
integrator complex subunit 3 |
| Synonyms gene: |
C1orf60 |
| Synonyms gene name: |
chromosome 1 open reading frame 60 |
| Synonyms name: |
sensor of single-strand DNA complex subunit A |
| Locus: |
1q21, 3 |
| Discovery year: |
2005-05-13 |
| GenBank acession: |
BX640950 |
| Entrez gene record: |
65123 |
| Pubmed identfication: |
16239144 |
| RefSeq identity: |
NM_023015 |
| Classification: |
Integrator complex |
| Havana BLAST/BLAT: |
OTTHUMG00000037089 |