| Long name: |
Biotin Conjugated, MTM1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
MTM1 |
| Specificity: |
This is a highly specific antibody against MTM1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human MTM1/Myotubularin |
| Gene ID number: |
4534 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Human MTM1, Myotubularin is primarily a lipid phosphatase that acts on phosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI3-kinase) pathway and membrane trafficking, The gene for MTM1 is localized to a 300 kb critical region on human Xq128 between IDS and GRBRA3, The gene responsible for myotubular myopathy MTM1 encodes a dual specificity phosphatase, The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-Tooth neuropathy, Thus, Wild-type myotubularin can directly dephosphorylate PI3P and PI4P in vitro, a 603 amino-acid protein, in most cases, is mutated in myotubular myopathy, it decreases PI3P levels by down-regulating PI3K activity and by facilitating the degradation of PI3P, leads to early postnatal death, named myotubularin, which is highly conserved through evolution, X-linked recessive myotubular myopathy is a congenital muscular disease characterized by severe hypotonia and generalized muscle weakness that |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
MTM1 Conjugated |
| Short name: |
Conjugated, MTM1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, MTM1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7448 |
| Gene: |
MTM1 |
More about : MTM1 |
| Long gene name: |
myotubularin 1 |
| Synonyms gene name: |
myotubular myopathy 1 |
| Locus: |
Xq28 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
U46024 |
| Entrez gene record: |
4534 |
| RefSeq identity: |
NM_000252 |
| Classification: |
Phosphoinositide phosphatases Myotubularins |
| Havana BLAST/BLAT: |
OTTHUMG00000024158 |
| Locus Specific Databases: |
Leiden Muscular Dystrophy pages Mental Retardation database LRG_839 |