| Long name: |
MTM1 Primary Polyclonal Antibody |
| Also known as: |
MTM1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
MTM1 |
| Specificity: |
This is a highly specific antibody against MTM1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MTM1/Myotubularin |
| Gene ID number: |
4534 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Human MTM1, Myotubularin is primarily a lipid phosphatase that acts on phosphatidylinositol 3-monophosphate and is involved in the regulation of the phosphatidylinositol 3-kinase (PI3-kinase) pathway and membrane trafficking, The gene for MTM1 is localized to a 300 kb critical region on human Xq128 between IDS and GRBRA3, The gene responsible for myotubular myopathy MTM1 encodes a dual specificity phosphatase, The largely related protein hMTMR2 is found mutated in a recessive form of Charcot-Marie-Tooth neuropathy, Thus, Wild-type myotubularin can directly dephosphorylate PI3P and PI4P in vitro, a 603 amino-acid protein, in most cases, is mutated in myotubular myopathy, it decreases PI3P levels by down-regulating PI3K activity and by facilitating the degradation of PI3P, leads to early postnatal death, named myotubularin, which is highly conserved through evolution, X-linked recessive myotubular myopathy is a congenital muscular disease characterized by severe hypotonia and generalized muscle weakness that |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CNM, KIAA4176, MTM1_HUMAN, MTMX, Mtm, Mtm1, Myotubular myopathy 1, Myotubularin, XLMTM, mKIAA4176, CG2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
MTM1 |
| Short name: |
MTM1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
MTM1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7448 |
| Gene: |
MTM1 |
More about : MTM1 |
| Long gene name: |
myotubularin 1 |
| Synonyms gene name: |
myotubular myopathy 1 |
| Locus: |
Xq28 |
| Discovery year: |
2001-06-22 |
| GenBank acession: |
U46024 |
| Entrez gene record: |
4534 |
| RefSeq identity: |
NM_000252 |
| Classification: |
Phosphoinositide phosphatases Myotubularins |
| Havana BLAST/BLAT: |
OTTHUMG00000024158 |
| Locus Specific Databases: |
Leiden Muscular Dystrophy pages Mental Retardation database LRG_839 |