| Long name: |
ALEXA FLUOR 350 Conjugated, NEDD4 Polyclonal Antibody |
| Also known as: |
Anti-NEDD4 PAb ALEXA FLUOR 350 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
350, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
NEDD4 |
| Specificity: |
This is a highly specific antibody against NEDD4 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
861-890/1319 |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NEDD4 |
| Gene ID Number: |
4734 |
| Swiss Prot: |
P46934 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable, Involved in the budding of many viruses, Involved in the pathway leading to the degradation of VEGFR-2/KDFR, Involved in the ubiquitination of ebola virus VP40 protein and this ubiquitination plays a role in facilitating viral budding, Involved in ubiquitination of ERBB4 intracellular domain E4ICD, Monoubiquitinates IGF1R at multiple sites, Part of a signaling complex composed of NEDD4, Promotes ubiquitination of RAPGEF2, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development, Ubiquitinates FGFR1, Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2, independently of its ubiquitin-ligase activity, leading to receptor internalization and degradation in lysosomes, thus leading to receptor internalization and degradation in lysosomes, E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
343nm/442nm |
| Synonyms: |
KIAA0093 MGC176705 NEDD4-1 RPF1 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 350, Alexa Fluor |
| Gene target: |
NEDD4 |
| Short name: |
NEDD4 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 350 |
| Alternative name: |
ALEXA FLUOR 350, NEDD4 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7727 |
| Gene: |
NEDD4 |
More about : NEDD4 |
| Long gene name: |
E3 ubiquitin protein ligase , developmentally down-regulated 4, neural precursor cell expressed |
| Synonyms gene name: |
developmentally down-regulated 4 , neural precursor cell expressed |
| Synonyms name: |
receptor-potentiating factor 1 |
| Locus: |
15q21, 3 |
| Discovery year: |
1994-01-21 |
| GenBank acession: |
D42055 |
| Entrez gene record: |
4734 |
| Pubmed identfication: |
9073511 8649367 |
| RefSeq identity: |
NM_198400 |
| Havana BLAST/BLAT: |
OTTHUMG00000132015 |