| Long name: |
ALEXA FLUOR 488 Conjugated, Myosin VIIa Polyclonal Antibody |
| Also known as: |
Anti-Myosin VIIa PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Myosin VIIa |
| Specificity: |
This is a highly specific antibody against Myosin VIIa |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
875-910/2215 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Myosin VIIa |
| Gene ID Number: |
4647 |
| Swiss Prot: |
Q13402 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells, In the inner ear, In the retina, Involved in hair-cell vesicle trafficking of aminoglycosides, Motor protein that is a part of the functional network formed by USH1C, Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, Required for normal hearing, Their highly divergent tails bind to membranous compartments, USH1G, Unconventional myosins serve in intracellular movements, and in the regulation of opsin transport in retinal photoreceptors, morphogenesis and organization of cochlear hair cell bundles, plays an important role in differentiation, plays an important role in the renewal of the outer photoreceptor disks, which are known to induce ototoxicity (By similarity), which are then moved relative to actin filaments, Myosins are actin-based motor molecules with ATPase activity |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
NSRD2 MYO7A |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the Myosin VIIa Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
Myosin VIIa |
| Short name: |
Myosin VIIa Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, Myosin VIIa (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2784 |
| Gene: |
DFNA11 |
More about : DFNA11 |
| Long gene name: |
myosin VIIA |
| Synonyms gene: |
USH1B DFNB2 |
| Synonyms gene name: |
myosin VIIA (Usher syndrome 1B (autosomal recessive, severe)) |
| Locus: |
11q13, 5 |
| Discovery year: |
1992-06-08 |
| GenBank acession: |
U39226 |
| Entrez gene record: |
4647 |
| Pubmed identfication: |
8884266 |
| RefSeq identity: |
NM_000260 |
| Classification: |
Myosins, class VII A-kinase anchoring proteins Deafness associated genes FERM domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000152822 |
| Locus Specific Databases: |
Hereditary Hearing Loss Homepage Mutations of the Myosin VIIa Gene CCHMC-BMI &, UC Hearing Loss Mutation Database |