| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
Myosin VIIa |
| Specificity: |
This antibody reacts specifically with Myosin VIIa |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Subcellular locations: |
Cytoplasm |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human Myosin VIIa |
| Gene ID: |
4647 |
| Swiss Prot: |
Q13402 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells, In the inner ear, In the retina, Involved in hair-cell vesicle trafficking of aminoglycosides, Motor protein that is a part of the functional network formed by USH1C, Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, Required for normal hearing, Their highly divergent tails bind to membranous compartments, USH1G, Unconventional myosins serve in intracellular movements, and in the regulation of opsin transport in retinal photoreceptors, morphogenesis and organization of cochlear hair cell bundles, plays an important role in differentiation, plays an important role in the renewal of the outer photoreceptor disks, which are known to induce ototoxicity (By similarity), which are then moved relative to actin filaments, Myosins are actin-based motor molecules with ATPase activity |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
NSRD2 MYO7A |
| Also known as: |
Myosin VIIa Polyclonal Antibody |
| Other name: |
Anti-Myosin VIIa Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
Myosin VIIa |
| Short name: |
Anti-Myosin VIIa (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-Myosin VIIa (polyclonal) |
| Alternative technique: |
polyclonals |
| Identity: |
2784 |
| Gene: |
DFNA11 |
More about : DFNA11 |
| Long gene name: |
myosin VIIA |
| Synonyms gene: |
USH1B DFNB2 |
| Synonyms gene name: |
myosin VIIA (Usher syndrome 1B (autosomal recessive, severe)) |
| Locus: |
11q13, 5 |
| Discovery year: |
1992-06-08 |
| GenBank acession: |
U39226 |
| Entrez gene record: |
4647 |
| Pubmed identfication: |
8884266 |
| RefSeq identity: |
NM_000260 |
| Classification: |
Myosins, class VII A-kinase anchoring proteins Deafness associated genes FERM domain containing |
| Havana BLAST/BLAT: |
OTTHUMG00000152822 |
| Locus Specific Databases: |
Hereditary Hearing Loss Homepage Mutations of the Myosin VIIa Gene CCHMC-BMI &, UC Hearing Loss Mutation Database |