| Long name: |
Supervillin Primary Polyclonal Antibody |
| Also known as: |
Supervillin PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Supervillin |
| Specificity: |
This is a highly specific antibody against Supervillin |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
80-130/2214 |
| Subcellular location: |
Cell membrane |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Supervillin |
| Gene ID number: |
6840 |
| Swiss Prot: |
O95425 |
| Tested Applications: |
IF(IHC-P), IHC-P |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Appears to be involved in myosin II assembly, Isoform 1 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation, Isoform 2 may be involved in modulation of focal adhesions, May modulate myosin II regulation through MLCK during cell spreading, May play a role in invadopodial function, Plays a role in cytokinesis through KIF14 interaction (By similarity), Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6, an initial step in cell migration, Forms a high-affinity link between the actin cytoskeleton and the membrane |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Archvillin, SVIL, p205/p250, Supervillin |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Supervillin |
| Short name: |
Supervillin Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Supervillin (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11480 |
| Gene: |
SVIL |
More about : SVIL |
| Long gene name: |
supervillin |
| Synonyms name: |
archvillin |
| Locus: |
10p11, 23 |
| Discovery year: |
1998-05-07 |
| GenBank acession: |
AF051851 |
| Entrez gene record: |
6840 |
| Pubmed identfication: |
9382871 |
| Classification: |
Gelsolin/villins |
| Havana BLAST/BLAT: |
OTTHUMG00000017882 |