| Long name: |
Caspase-8 subunit p18 Antibody |
| Also known as: |
Caspase-8 subunit p18 Antibody |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Caspase-8 subunit p18 |
| Specificity: |
This is a highly specific antibody against Caspase-8 subunit p18 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
217-244/479 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Caspase-8 subunit p18 |
| Gene ID number: |
841 |
| Swiss Prot: |
Q14790 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Ac-Asp-Glu-Val-Asp-|-AMC, Binding to the adapter molecule FADD recruits it to either receptor, CAP5 and CAP6) are likely retained in the DISC, CASP4, CASP6, CASP7, CASP9 and CASP10, Cleaves ADPRT, Cleaves and activates CASP3, Hydrolyzes the small-molecule substrate, Isoform 5, Likely target for the cowpox virus CRMA death inhibitory protein, May participate in the GZMB apoptotic pathways, Proteolytic fragments of the N-terminal propeptide (termed CAP3, The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases, The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex, Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ALPS2B, Apoptotic cysteine protease, Apoptotic protease Mch-5, CASP8, Casp-8, Caspase-8, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MACH, MCH5, MORT1-associated ced-3 homolog, CAP4 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Caspase-8 subunit p18 |
| Short name: |
Caspase-8 subunit p18 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
caspase-8 functionnal sequence p18 (Antibody to) |
| Alternative technique: |
antibodies |