| Long name: |
ALEXA FLUOR 350 Conjugated, Caspase-8 subunit p18 Antibody |
| Also known as: |
Anti-Caspase-8 subunit p18 PAb ALEXA FLUOR 350 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
350, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Caspase-8 subunit p18 |
| Specificity: |
This is a highly specific antibody against Caspase-8 subunit p18 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
217-244/479 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Caspase-8 subunit p18 |
| Gene ID Number: |
841 |
| Swiss Prot: |
Q14790 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Ac-Asp-Glu-Val-Asp-|-AMC, Binding to the adapter molecule FADD recruits it to either receptor, CAP5 and CAP6) are likely retained in the DISC, CASP4, CASP6, CASP7, CASP9 and CASP10, Cleaves ADPRT, Cleaves and activates CASP3, Hydrolyzes the small-molecule substrate, Isoform 5, Likely target for the cowpox virus CRMA death inhibitory protein, May participate in the GZMB apoptotic pathways, Proteolytic fragments of the N-terminal propeptide (termed CAP3, The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases, The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex, Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
343nm/442nm |
| Synonyms: |
ALPS2B, Apoptotic cysteine protease, Apoptotic protease Mch-5, CASP8, Casp-8, Caspase-8, FADD-homologous ICE/ced-3-like protease, FADD-like ICE, FLICE, ICE-like apoptotic protease 5, MACH, MCH5, MORT1-associated ced-3 homolog, CAP4 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 350, Alexa Fluor |
| Gene target: |
Caspase-8 subunit p18 |
| Short name: |
Caspase-8 subunit p18 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 350 |
| Alternative name: |
ALEXA FLUOR 350, caspase-8 functionnal sequence p18 (Antibody to) |
| Alternative technique: |
antibodies |