| Long name: |
Biotin Conjugated, PPP4C Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
PPP4C |
| Specificity: |
This is a highly specific antibody against PPP4C |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human PPP4C |
| Gene ID number: |
5531 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
DNA damage checkpoint signaling, DNA repair, Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity), In response to DNA damage, NF-kappa-B activation and cell migration, The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3, The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair, activation of c-Jun N-terminal kinase MAPK8, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin, apoptosis, catalyzes RPA2 dephosphorylation, maturation of spliceosomal snRNPs, regulation of histone acetylation, tumor necrosis factor (TNF)-alpha signaling, Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
PP4 PPX |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
PPP4C Conjugated |
| Short name: |
Conjugated, PPP4C Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, PPP4C (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
9319 |
| Gene: |
PPP4C |
More about : PPP4C |
| Long gene name: |
protein phosphatase 4 catalytic subunit |
| Synonyms gene name: |
catalytic subunit , catalytic subunit protein phosphatase 4, protein phosphatase 4 (formerly X) |
| Synonyms name: |
catalytic subunit , protein phosphatase X |
| Locus: |
16p11, 2 |
| Discovery year: |
1993-01-22 |
| Entrez gene record: |
5531 |
| Pubmed identfication: |
9177794 |
| RefSeq identity: |
NM_002720 |
| Classification: |
Protein phosphatase catalytic subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000132113 |