| Long name: |
ASAH2 Primary Polyclonal Antibody |
| Also known as: |
ASAH2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
ASAH2 |
| Specificity: |
This is a highly specific antibody against ASAH2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human ASAH2 |
| Gene ID number: |
2298 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Acts as a key regulator of sphingolipid signaling metabolites by generating sphingosine at the cell surface, Acts as a repressor of apoptosis both by reducing C16-ceramide, Probably involved in the digestion of dietary sphingolipids in intestine by acting as a key enzyme for the catabolism of dietary sphingolipids and regulating the levels of bioactive sphingolipid metabolites in the intestinal tract, a precursor of the antiapoptotic factor sphingosine 1-phosphate, and generating sphingosine, thereby preventing ceramide-induced apoptosis, 5, 5-8, Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 6 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ASAH2, ASAH2_HUMAN, BCDase, HNAC1, LCDase, MGC129777, N CDase, N acylsphingosine amidohydrolase 2, N acylsphingosine amidohydrolase non lysosomal ceramidase 2, N-CDase, N-acylsphingosine amidohydrolase 2, NCDase, Neutral ceramidase soluble form, Non lysosomal ceramidase, Non-lysosomal ceramidase, hCD, mitochondrial ceramidase, Acylsphingosine deacylase 2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
ASAH2 |
| Short name: |
ASAH2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
N-acylsphin this GO sine amidohydrolase (non-lysosomal ceramidase) 2 (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
ASAH2 and IDBG-74349 and ENSG00000188611 and 56624, Plasma membranes, ceramidase activity, this GO :0005739 and mitochondrion and cellular component this GO :0005886 and plasma membrane and cellular component this GO :0006665 and sphin this GO lipid metabolic process and biological process this GO :0006672 and ceramide metabolic process and biological process this GO :0006687 and glycosphin this GO lipid metabolic process and biological process this GO :0006915 and apoptotic process and biological process this GO :0007165 and signal transduction and biological process this GO :0016021 and integral component of membrane and cellular component this GO :0017040 and ceramidase activity and molecular function this GO :0044281 and small molecule metabolic process and biological process, this GO :0017040 : ceramidase activity, this GO :0017040 : ceramidase activity, N-acylsphin this GO sine amidohydrolase (non-lysosomal ceramidase) 2 |
| Identity: |
18860 |
| Gene: |
ASAH2 |
More about : ASAH2 |
| Long gene name: |
N-acylsphingosine amidohydrolase 2 |
| Synonyms gene name: |
N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 |
| Synonyms name: |
neutral ceramidase non-lysosomal ceramidase |
| Locus: |
10q11, 23 |
| Discovery year: |
2002-07-05 |
| GenBank acession: |
AF250847 |
| Entrez gene record: |
56624 |
| Pubmed identfication: |
10781606 |
| RefSeq identity: |
NM_019893 |
| Havana BLAST/BLAT: |
OTTHUMG00000018223 |