| Long name: |
FITC Conjugated, PKC beta 1 (Ser642) Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
PKC beta 1 Ser642 |
| Specificity: |
This is a highly specific antibody against PKC beta 1 Ser642 |
| Modification: |
Phosphorylation |
| Modification site: |
Ser642 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human PKC beta 1 around the phosphorylation site of Ser642 |
| Gene ID number: |
5579 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
'Ser-644' and 'Ser-652', Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, In insulin signaling, Involved in apoptosis following oxidative damage: in case of oxidative conditions, May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4, Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, Plays a direct role in the negative feedback regulation of the BCR signaling, Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation, a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A, androgen receptor-dependent transcription regulation, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', insulin signaling and endothelial cells proliferation, leading to mitochondrial accumulation of p66Shc, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade, oxidative stress-induced apoptosis, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, resulting in nuclear translocation and activation of NFKB1, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, where p66Shc acts as a reactive oxygen species producer, which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity, which then activates IKK complex, Calcium-activated |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
FLJ25513 DKFZp547J199 IFITMD1 FICCA DSPB3 PKC EKD1 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
PKC beta 1 (Ser642) Conjugated |
| Short name: |
FITC Conjugated, PKC beta 1 (Ser642) Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, PKC b 1 (Ser642) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
30500 |
| Gene: |
PRRT2 |
More about : PRRT2 |
| Long gene name: |
proline rich transmembrane protein 2 |
| Synonyms gene: |
ICCA DYT10 |
| Synonyms gene name: |
infantile convulsions and paroxysmal choreoathetosis dystonia 10 proline-rich transmembrane protein 2 |
| Synonyms name: |
interferon induced transmembrane protein domain containing 1 |
| Locus: |
16p11, 2 |
| Discovery year: |
2005-11-25 |
| GenBank acession: |
BC011405 |
| Entrez gene record: |
112476 |
| Pubmed identfication: |
22101681 22243967 |
| RefSeq identity: |
NM_145239 |
| Classification: |
Proline rich transmembrane proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000177142 |