| Long name: |
PKC beta 1 (Ser642) Primary Polyclonal Antibody |
| Also known as: |
PKC beta 1 (Ser642) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
PKC beta 1 Ser642 |
| Specificity: |
This is a highly specific antibody against PKC beta 1 Ser642 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Ser642 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human PKC beta 1 around the phosphorylation site of Ser642 |
| Gene ID number: |
5579 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
'Ser-644' and 'Ser-652', Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, In insulin signaling, Involved in apoptosis following oxidative damage: in case of oxidative conditions, May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4, Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, Plays a direct role in the negative feedback regulation of the BCR signaling, Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation, a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A, androgen receptor-dependent transcription regulation, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', insulin signaling and endothelial cells proliferation, leading to mitochondrial accumulation of p66Shc, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade, oxidative stress-induced apoptosis, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, resulting in nuclear translocation and activation of NFKB1, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, where p66Shc acts as a reactive oxygen species producer, which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity, which then activates IKK complex, Calcium-activated |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
PKC-B, PKC-beta, PKCB, PRKCB, PRKCB1, Protein kinase C beta type |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
PKC beta 1 (Ser642) |
| Short name: |
PKC beta 1 (Ser642) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
PKC b 1 (Ser642) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
30500 |
| Gene: |
PRRT2 |
More about : PRRT2 |
| Long gene name: |
proline rich transmembrane protein 2 |
| Synonyms gene: |
ICCA DYT10 |
| Synonyms gene name: |
infantile convulsions and paroxysmal choreoathetosis dystonia 10 proline-rich transmembrane protein 2 |
| Synonyms: |
FLJ25513 DKFZp547J199 IFITMD1 FICCA DSPB3 PKC EKD1 |
| Synonyms name: |
interferon induced transmembrane protein domain containing 1 |
| Locus: |
16p11, 2 |
| Discovery year: |
2005-11-25 |
| GenBank acession: |
BC011405 |
| Entrez gene record: |
112476 |
| Pubmed identfication: |
22101681 22243967 |
| RefSeq identity: |
NM_145239 |
| Classification: |
Proline rich transmembrane proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000177142 |