| Long name: |
ALEXA FLUOR 488 Conjugated, CD95 (Tyr291) Polyclonal Antibody |
| Also known as: |
Anti-CD95 Tyr291 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
CD95 Tyr291 |
| Specificity: |
This is a highly specific antibody against CD95 Tyr291 |
| Modification: |
Phosphorylation |
| Modification Site: |
Tyr291 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Subcellular location: |
Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human FAS around the phosphorylation site of Tyr291 |
| Gene ID Number: |
355 |
| Swiss Prot: |
P25445 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, The adapter molecule FADD recruits caspase-8 to the activated receptor, The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis, The secreted isoforms 2 to 6 block apoptosis (in vitro), in the antigen-stimulated suicide of mature T-cells, or both, Receptor for TNFSF6/FASLG |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
CD95 APO-1 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the CD95 (Tyr291) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
CD95 (Tyr291) |
| Short name: |
CD95 (Tyr291) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, CD95 (Tyr291) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11920 |
| Gene: |
FAS |
More about : FAS |
| Long gene name: |
Fas cell surface death receptor |
| Synonyms gene: |
FAS1 APT1 TNFRSF6 |
| Synonyms gene name: |
member 6 Fas (TNF receptor superfamily, member 6) , tumor necrosis factor receptor superfamily |
| Synonyms name: |
TNF receptor superfamily member 6 |
| Locus: |
10q23, 31 |
| Discovery year: |
1992-06-25 |
| GenBank acession: |
M67454 |
| Entrez gene record: |
355 |
| Pubmed identfication: |
1385299 1385309 |
| Classification: |
CD molecules Tumor necrosis factor receptor superfamily Death inducing signaling complex |
| Havana BLAST/BLAT: |
OTTHUMG00000018701 |
| Locus Specific Databases: |
Autoimmune Lymphoproliferative Syndrome Database (ALPSbase): Database of mutations causing human ALPS LOVD at NCBI LRG_134 |