| Long name: |
CDKN1A (Ser146) Primary Polyclonal Antibody |
| Also known as: |
CDKN1A (Ser146) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
CDKN1A Ser146 |
| Specificity: |
This is a highly specific antibody against CDKN1A Ser146 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Ser146 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human CDKN1A around the phosphorylation site of Ser146 [QT(p-S)MT] |
| Gene ID number: |
1026 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, The expression of this gene is tightly controlled by the tumor suppressor protein p53, The p16INK4a family inhibits Cdk4 and Cdk6 specifically, The p21WAF1/Cip1 family inhibits all kinases involved in the G1/S transition, This protein can interact with proliferating cell nuclear antigen (PCNA), This protein was reported to be specifically cleaved by CASP3-like caspases, Two alternatively spliced variants, Two families of cyclin dependent kinase inhibitors (CKIs) have been identified, a DNA polymerase accessory factor, and may be instrumental in the execution of apoptosis following caspase activation, and plays a regulatory role in S phase DNA replication and DNA damage repair, and thus functions as a regulator of cell cycle progression at G1, have been reported, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli, which encode an identical protein, which thus leads to a dramatic activation of CDK2, This gene encodes a potent cyclin-dependent kinase inhibitor |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
CAP20, CDK Interacting Protein 1, CDK-interacting protein 1, CDKI, CDKN 1, CDKN1, CDKN1A, CIP1, Cation chloride cotransporter-interacting protein 1, Cip1, Cyclin Dependent Kinase Inhibitor 1A, Cyclin-dependent kinase inhibitor 1, Cyclin-dependent kinase inhibitor 1A P21, Cyclin-dependent kinase inhibitor 1A p21, DNA Synthesis Inhibitor, MDA 6, MDA-6, MDA6, Melanoma Dferentiation Associated Protein 6, Melanoma dferentiation-associated protein, Melanoma dferentiation-associated protein 6, P21 protein, PIC1, SDI1, SLC12A9, WAF1, Wildtype p53 Activating Fragment 1, Wildtype p53-activated fragment 1, p21, p21CIP1, p21WAF, Activating Fragment 1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
CDKN1A (Ser146) |
| Short name: |
CDKN1A (Ser146) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Cip1) (Ser146) (Antibody to), cyclin-dependent kinase inhibitor 1A (p21 |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
CAP20 and CDKN1 and CIP1 and MDA-6 and P21 and p21CIP1 and SDI1 and WAF1, CDKN1A and IDBG-630156 and ENSBTAG00000008353 and 513497, CDKN1A and IDBG-85033 and ENSG00000124762 and 1026, Cdkn1a and IDBG-159848 and ENSMUSG00000023067 and 12575, Cip1), metal ion binding, nuclei, signal transduction by p53 class mediator resulting in cell cycle arrest and biological process this GO :0007050 and cell cycle arrest and biological process this GO :0007173 and epidermal growth factor receptor signaling pathway and biological process this GO :0007265 and Ras protein signal transduction and biological process this GO :0007346 and regulation of mitotic cell cycle and biological process this GO :0008285 and negative regulation of cell proliferation and biological process this GO :0008543 and fibroblast growth factor receptor signaling pathway and biological process this GO :0009411 and response to UV and biological process this GO :0009636 and response to toxic substance and biological process this GO :0010033 and response to organic substance and biological process this GO :0010165 and response to X-ray and biological process this GO :0010243 and response to organonitrogen compound and biological process this GO :0010629 and negative regulation of gene expression and biological process this GO :0014070 and response to organic cyclic compound and biological process this GO :0019912 and cyclin-dependent protein kinase activating kinase activity and molecular function this GO :0030308 and negative regulation of cell growth and biological process this GO :0030332 and cyclin binding and molecular function this GO :0030890 and positive regulation of B cell proliferation and biological process this GO :0031100 and organ regeneration and biological process this GO :0031668 and cellular response to extracellular stimulus and biological process this GO :0032403 and protein complex binding and molecular function this GO :0033158 and regulation of protein import into nucleus, this GO :0000079 and regulation of cyclin-dependent protein serine/threonine kinase activity and biological process this GO :0000082 and G1/S transition of mitotic cell cycle and biological process this GO :0000086 and G2/M transition of mitotic cell cycle and biological process this GO :0000278 and mitotic cell cycle and biological process this GO :0000307 and cyclin-dependent protein kinase holoenzyme complex and cellular component this GO :0004861 and cyclin-dependent protein serine/threonine kinase inhibitor activity and molecular function this GO :0005515 and protein binding and molecular function this GO :0005634 and nucleus and cellular component this GO :0005654 and nucleoplasm and cellular component this GO :0005737 and cytoplasm and cellular component this GO :0005829 and cytosol and cellular component this GO :0006468 and protein phosphorylation and biological process this GO :0006974 and cellular response to DNA damage stimulus and biological process this GO :0006977 and DNA damage response, this GO :0004861 : cyclin-dependent protein serine/threonine kinase inhibitor activity, this GO :0004861 : cyclin-dependent protein serine/threonine kinase inhibitor activity and also this GO :0005515 : protein binding and also this GO :0019912 : cyclin-dependent protein kinase activating kinase activity and also this GO :0030332 : cyclin binding and also this GO :0032403 : protein complex binding and also this GO :0046872 : metal ion binding, this GO :0005515 : protein binding, this GO :0019912 : cyclin-dependent protein kinase activating kinase activity, this GO :0030332 : cyclin binding, this GO :0032403 : protein complex binding, this GO :0046872 : metal ion binding, translocation and biological process this GO :0034605 and cellular response to heat and biological process this GO :0038095 and Fc-epsilon receptor signaling pathway and biological process this GO :0042326 and negative regulation of phosphorylation and biological process this GO :0042493 and response to drug and biological process this GO :0042771 and intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and biological process this GO :0043066 and negative regulation of apoptotic process and biological process this GO :0043068 and positive regulation of programmed cell death and biological process this GO :0043231 and intracellular membrane-bounded organelle and cellular component this GO :0045087 and innate immune response and biological process this GO :0045736 and negative regulation of cyclin-dependent protein serine/threonine kinase activity and biological process this GO :0045860 and positive regulation of protein kinase activity and biological process this GO :0046685 and response to arsenic-containing substance and biological process this GO :0046872 and metal ion binding and molecular function this GO :0048011 and neurotrophin TRK receptor signaling pathway and biological process this GO :0048015 and phosphatidylinositol-mediated signaling and biological process this GO :0048146 and positive regulation of fibroblast proliferation and biological process this GO :0048471 and perinuclear region of cytoplasm and cellular component this GO :0051384 and response to glucocorticoid and biological process this GO :0051412 and response to corticosterone and biological process this GO :0051726 and regulation of cell cycle and biological process this GO :0055093 and response to hyperoxia and biological process this GO :0060574 and intestinal epithelial cell maturation and biological process this GO :0070557 and PCNA-p21 complex and cellular component this GO :0071479 and cellular response to ionizing radiation and biological process this GO :0071850 and mitotic cell cycle arrest and biological process this GO :0071901 and negative regulation of protein serine/threonine kinase activity and biological process this GO :0090398 and cellular senescence and biological process this GO :0090400 and stress-induced premature senescence and biological process this GO :0097193 and intrinsic apoptotic signaling pathway and biological process this GO :2000278 and regulation of DNA biosynthetic process and biological process this GO :2000379 and positive regulation of reactive oxygen species metabolic process and biological process, cyclin-dependent kinase inhibitor 1A (p21 |
| Identity: |
1784 |
| Gene: |
CDKN1A |
More about : CDKN1A |
| Long gene name: |
cyclin dependent kinase inhibitor 1A |
| Synonyms gene: |
CDKN1 |
| Synonyms gene name: |
Cip1) , cyclin-dependent kinase inhibitor 1A (p21 |
| Synonyms: |
P21 CIP1 WAF1 SDI1 CAP20 p21CIP1 p21Cip1/Waf1 |
| Locus: |
6p21, 2 |
| Discovery year: |
1994-05-24 |
| GenBank acession: |
U03106 |
| Entrez gene record: |
1026 |
| RefSeq identity: |
NM_078467 |
| Havana BLAST/BLAT: |
OTTHUMG00000014603 |