| Long name: |
FITC Conjugated, Bcl-xL (Thr115) Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Bcl-xL Thr115 |
| Specificity: |
This is a highly specific antibody against Bcl-xL Thr115 |
| Modification: |
Phosphorylation |
| Modification site: |
Thr115 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
95-140/233 |
| Subcellular location: |
Mitochondrion, Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human BCL2L1 around the phosphorylation site of Thr115 |
| Gene ID number: |
598 |
| Swiss Prot: |
Q07817 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis, Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, During synaptic stimulation, Inhibits activation of caspases, Isoform Bcl-X(L) also regulates presynaptic plasticity, Isoform Bcl-X(S) promotes apoptosis, from the mitochondrial membrane, including neurotransmitter release and recovery, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles, number of axonal mitochondria as well as size and number of synaptic vesicle clusters, Potent inhibitor of cell death |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
Apoptosis regulator Bcl-X, BCL-XL/S, BCL2L, BCL2L1, BCLXL, BCLXS, Bcl-2-like protein 1, Bcl-X, Bcl2-L-1, PPP1R52, bcl-xL, bcl-xS, BCLX |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Bcl-xL (Thr115) Conjugated |
| Short name: |
FITC Conjugated, Bcl-xL (Thr115) Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, Bcl-xL (Thr115) (Antibody to) |
| Alternative technique: |
antibodies |