| Long name: |
Bcl-xL (Thr115) Primary Polyclonal Antibody |
| Also known as: |
Bcl-xL (Thr115) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Bcl-xL Thr115 |
| Specificity: |
This is a highly specific antibody against Bcl-xL Thr115 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Thr115 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
95-140/233 |
| Subcellular location: |
Mitochondrion, Cytoplasm |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human BCL2L1 around the phosphorylation site of Thr115 |
| Gene ID number: |
598 |
| Swiss Prot: |
Q07817 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis, Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, During synaptic stimulation, Inhibits activation of caspases, Isoform Bcl-X(L) also regulates presynaptic plasticity, Isoform Bcl-X(S) promotes apoptosis, from the mitochondrial membrane, including neurotransmitter release and recovery, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles, number of axonal mitochondria as well as size and number of synaptic vesicle clusters, Potent inhibitor of cell death |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Apoptosis regulator Bcl-X, BCL-XL/S, BCL2L, BCL2L1, BCLXL, BCLXS, Bcl-2-like protein 1, Bcl-X, Bcl2-L-1, PPP1R52, bcl-xL, bcl-xS, BCLX |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Bcl-xL (Thr115) |
| Short name: |
Bcl-xL (Thr115) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Bcl-xL (Thr115) (Antibody to) |
| Alternative technique: |
antibodies |