| Long name: |
MSK2 Primary Polyclonal Antibody |
| Also known as: |
MSK2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
MSK2 |
| Specificity: |
This is a highly specific antibody against MSK2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Source: |
Synthetic peptide |
| Gene ID number: |
8986 |
| Swiss Prot: |
O75676 |
| Tested Applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P, 000), WB (1:2 |
| Cross reactivity: |
Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), In lipopolysaccharide-stimulated primary macrophages, May also phosphorylate 'Ser-28' of histone H3, Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14), Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, Plays an essential role in the control of RELA transcriptional activity in response to TNF, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes, epidermal growth factor (EGF) and anisomycin, including proto-oncogenes c-fos/FOS and c-jun/JUN, stress stimuli and EGF, via CREB1 and ATF1 transcription factors, which results in the transcriptional activation of several immediate early genes, Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
90 kDa ribosomal protein S6 kinase 4, Nuclear mitogen- and stress-activated protein kinase 2, RPS6KA4, RSK-B, RSKB, Ribosomal protein S6 kinase alpha-4, Ribosomal protein kinase B, S6K-alpha-4, MSK2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
MSK2 |
| Short name: |
MSK2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
MSK2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
10433 |
| Gene: |
RPS6KA4 |
More about : RPS6KA4 |
| Long gene name: |
ribosomal protein S6 kinase A4 |
| Synonyms gene name: |
90kD, polypeptide 4 , ribosomal protein S6 kinase |
| Synonyms: |
RSK-B MSK2 |
| Locus: |
11q13, 1 |
| Discovery year: |
1999-03-10 |
| GenBank acession: |
AJ010119 |
| Entrez gene record: |
8986 |
| Pubmed identfication: |
9792677 9687510 |
| RefSeq identity: |
NM_003942 |
| Classification: |
Mitogen-activated protein kinase-activated protein kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000046094 |