| Long name: |
NR2C2/TAK1 Primary Polyclonal Antibody |
| Also known as: |
NR2C2/TAK1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
NR2C2/TAK1 |
| Specificity: |
This antibody may have a minor secondary cross-reactivity towards NR2C1 in human and rat, based upon a non-sequential 77% sequence similarity over the immunogen range, This is a highly specific antibody against NR2C2/TAK1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
490-540/596 |
| Subcellular location: |
Nucleus |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human NR2C2/TAK1 |
| Gene ID number: |
7182 |
| Swiss Prot: |
P49116 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Activates transcriptional activity of LHCG, An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, Antagonist of PPARA-mediated transactivation, Appears to be important for neurodevelopmentally regulated behavior (By similarity), Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences, May regulate gene expression during the late phase of spermatogenesis, Plays a fundamental role in early embryonic development and embryonic stem cells, Required for normal spermatogenesis and cerebellum development, Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1, retinoid X, thyroid hormone receptor and estrogen receptor pathways, vitamin D3 receptor, Orphan nuclear receptor that can act as a repressor or activator of transcription |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
NR2C2, Nuclear receptor subfamily 2 group C member 2, Orphan nuclear receptor TAK1, Orphan nuclear receptor TR4, TAK1, Testicular receptor 4, TR4 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
NR2C2/TAK1 |
| Short name: |
NR2C2/TAK1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
NR2C2/TAK1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
7972 |
| Gene: |
NR2C2 |
More about : NR2C2 |
| Long gene name: |
nuclear receptor subfamily 2 group C member 2 |
| Synonyms gene: |
TR4 |
| Synonyms gene name: |
group C, member 2 , nuclear receptor subfamily 2 |
| Synonyms: |
TAK1 TR2R1 hTAK1 |
| Locus: |
3p25, 1 |
| Discovery year: |
1998-05-15 |
| GenBank acession: |
L27586 |
| Entrez gene record: |
7182 |
| Pubmed identfication: |
8661150 8016112 |
| RefSeq identity: |
NM_003298 |
| Classification: |
Nuclear hormone receptors |
| Havana BLAST/BLAT: |
OTTHUMG00000129839 |