Cullin 3 Antibody, Biotin Conjugated

Catalog number:	bs-4211R-Biotin Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies
Product name:	Cullin 3 Antibody, Biotin Conjugated
Quantity:	0.1ml
Related search:	cullin antibody antibodies ubiquitination ligase pubmed the ubiquitin

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Long name:	Biotin Conjugated, Cullin 3 Polyclonal Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	Biotinylated
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	Cullin 3
Specificity:	This antibody may detect Cullin-4 A/B, This is a highly specific antibody against Cullin 3
Modification:	Unmodified
Modification site:	None
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen_range:	430-480/768
Subcellular location:	Nucleus
Source:	KLH conjugated synthetic peptide derived from human Cullin 3
Gene ID number:	8452
Swiss Prot:	Q13618
Tested applications:	IHC-P, WB
Recommended dilutions:	IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity:	Mouse, Rat, Human
Crossreactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background:	As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme, BCR(KLHL12) is involved in ER-Golgi transport by regulating the size of COPII coats, BCR(KLHL3) acts as a regulator of ion transport in the distal nephron, BCR(KLHL42) is involved in ubiquitination of KATNA1, BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis, BCR(SPOP) is involved in ubiquitination of BMI1/PCGF4, BRMS1, Can also form a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOPL or the heterodimer formed by SPOP and SPOPL, GLI2 and GLI3, H2AFY and DAXX, PubMed:21670212, PubMed:21840486, PubMed:24768539), The BCR(KLHL20) E3 ubiquitin ligase complex is involved in interferon response and anterograde Golgi to endosome transport: it mediates both ubiquitination leading to degradation and 'Lys-33'-linked ubiquitination (PubMed:20389280, The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity), The functional specificity of the BCR complex depends on the BTB domain-containing protein as the substrate recognition component, by mediating ubiquitination of WNK4, thereby playing a key role in collagen export, these complexes have lower ubiquitin ligase activity, which is required for embryonic stem (ES) cells division: BCR(KLHL12) acts by mediating monoubiquitination of SEC31 (SEC31A or SEC31B), Core component of multiple cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Synonyms:	CUL3, Cullin-3, KIAA0617, PHA2E, CUL-3
Properties:	Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene target:	Cullin 3 Conjugated
Short name:	Conjugated, Cullin 3 Antibody
Technique:	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	Biotin
Alternative name:	biotinilated coupled, Cullin 3 (Antibody to)
Alternative technique:	antibodies

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