| Long name: |
GEF H1 Primary Polyclonal Antibody |
| Also known as: |
GEF H1 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
GEF H1 |
| Specificity: |
This is a highly specific antibody against GEF H1 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
12-62/986 |
| Subcellular location: |
Cell membrane, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human GEF H1 |
| Gene ID number: |
9181 |
| Swiss Prot: |
Q92974 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Binds Rac-GTPases, Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2, Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens, Inactive toward CDC42, Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans, Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, May be involved in epithelial barrier permeability, May stimulate instead the cortical activity of Rac, Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S, TC10, acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase, and cancer, antigen presentation, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, cell cycle regulation, cell motility and polarization, dendritic spine morphology, innate immune response, leukemic cell differentiation, or Ras-GTPases, which was uniquely reported in PubMed:9857026, Activates Rho-GTPases by promoting the exchange of GDP for GTP, flexneri cell invasion |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
ARHGEF2, GEF-H1, GEFH1, Guanine nucleotide exchange factor H1, KIAA0651, LFP40, Microtubule-regulated Rho-GEF, P40, Proliferating cell nucleolar antigen p40, Rho guanine nucleotide exchange factor 2, GEF |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
GEF H1 |
| Short name: |
GEF H1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
GEF H1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
15930 |
| Gene: |
SLC2A4RG |
More about : SLC2A4RG |
| Long gene name: |
SLC2A4 regulator |
| Synonyms: |
GEF HDBP1 Si-1-2 Si-1-2-19 |
| Synonyms name: |
GLUT4 enhancer factor Huntington', s disease gene regulatory region-binding protein 1 |
| Locus: |
20q13, 33 |
| Discovery year: |
2001-06-21 |
| GenBank acession: |
AF249267 |
| Entrez gene record: |
56731 |
| Pubmed identfication: |
10825161 |
| RefSeq identity: |
NM_020062 |
| Havana BLAST/BLAT: |
OTTHUMG00000032997 |