| Long name: |
RPH3AL Primary Polyclonal Antibody |
| Also known as: |
RPH3AL PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
RPH3AL |
| Specificity: |
This is a highly specific antibody against RPH3AL |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human RPH3AL |
| Gene ID number: |
9501 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
It contains one FYVE-type zinc finger and one Rab-binding (RBD) domain, It is believed to play a role regulating calcium-dependent secretory vesicle exocytosis in endocrine and exocrine cells, Rabphilin-3AL is expressed in a variety of tissues, Rabphilin-3AL knockout mice display accumulation of secretory granules and irregular shape in exocrine cells, Through an interaction with Rab 3, Via its RBD domain, With lower affinity, also known as RPH3AL or NOC2, but unlike its related protein, heart and thyroid, is a cytoplasmic Rab GTPase effector, liver, ovary, pancreas, rabphilin-3A, rabphilin-3AL can also bind Rab 3 and Rab 8 with its RBD domain, rabphilin-3AL can inhibit G-protein signaling in endocrine pancreas and positively regulate insulin secretion, rabphilin-3AL does not contain any C2 domains, rabphilin-3AL is capable of binding Rab 27a and, rabphilin-3AL is recruited to dense-core vesicles, skeletal muscle, stomach, through this interaction, with highest levels found in kidney, Rabphilin-3AL (rabphilin-3A-like) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
Gm1753, No C2 domains protein, RPH3AL, RPH3L_HUMAN, Rab effector Noc2, Rabphilin 3A-like, Rabphilin 3A-like without C2 domains, Rabphilin-3A-like protein, Noc2 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
RPH3AL |
| Short name: |
RPH3AL Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
rabphilin 3A-like (without complement component 2 domains) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
Cytoplasm, NOC2, RPH3AL and IDBG-13853 and ENSG00000181031 and 9501, RPH3AL and IDBG-632666 and ENSBTAG00000039819 and 617294, Rph3al and IDBG-200631 and ENSMUSG00000020847 and 380714, metal ion binding, this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0006886 and intracellular protein transport and biological process this GO :0006887 and exocytosis and biological process this GO :0008092 and cytoskeletal protein binding and molecular function this GO :0017137 and Rab GTPase binding and molecular function this GO :0017158 and regulation of calcium ion-dependent exocytosis and biological process this GO :0030141 and secretory granule and cellular component this GO :0030274 and LIM domain binding and molecular function this GO :0030658 and transport vesicle membrane and cellular component this GO :0030667 and secretory granule membrane and cellular component this GO :0042493 and response to drug and biological process this GO :0042593 and glucose homeostasis and biological process this GO :0045744 and negative regulation of G-protein coupled receptor protein signaling pathway and biological process this GO :0046872 and metal ion binding and molecular function this GO :0050714 and positive regulation of protein secretion and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0008092 : cytoskeletal protein binding and also this GO :0017137 : Rab GTPase binding and also this GO :0030274 : LIM domain binding and also this GO :0046872 : metal ion binding, this GO :0008092 : cytoskeletal protein binding, this GO :0017137 : Rab GTPase binding, this GO :0030274 : LIM domain binding, this GO :0046872 : metal ion binding, rabphilin 3A-like (without C2 domains) |
| Identity: |
10296 |
| Gene: |
RPH3AL |
More about : RPH3AL |
| Long gene name: |
rabphilin 3A-like (without C2 domains) |
| Synonyms: |
Noc2 |
| Locus: |
17p13, 3 |
| Discovery year: |
1999-04-14 |
| Entrez gene record: |
9501 |
| Pubmed identfication: |
10395805 |
| RefSeq identity: |
NM_006987 |
| Havana BLAST/BLAT: |
OTTHUMG00000090273 |