| Type: |
Conjugated Primary Antibody |
| Conjugated with: |
594, ALEXA FLUOR® |
| Host organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Protein/Peptide: |
RPH3AL |
| Specificity: |
This antibody reacts specifically with RPH3AL |
| Modification: |
No modification has been applied to this antibody |
| Modification site: |
None |
| Clonality: |
Polyclonal Antibody |
| Clone: |
Polyclonal Antibodies |
| Concentration: |
1ug per 1ul |
| Antigen Source: |
KLH conjugated synthetic peptide derived from human RPH3AL |
| Gene ID: |
9501 |
| Applications: |
IF(IHC-P) |
| Applications with corresponding dilutions: |
IF(IHC-P)(1:50-200) |
| Cross reactive species: |
Mouse (Mus musculus), Rat (Rattus norvegicus), Human (Homo sapiens) |
| Cross Reactive Species details: |
However, note that due to limited knowledge it is impossible to predict with 100% guarantee that the antibody does not corss react with any other species, No significant cross reactivity has been observed for this antibody for the tested species |
| Background information: |
It contains one FYVE-type zinc finger and one Rab-binding (RBD) domain, It is believed to play a role regulating calcium-dependent secretory vesicle exocytosis in endocrine and exocrine cells, Rabphilin-3AL is expressed in a variety of tissues, Rabphilin-3AL knockout mice display accumulation of secretory granules and irregular shape in exocrine cells, Through an interaction with Rab 3, Via its RBD domain, With lower affinity, also known as RPH3AL or NOC2, but unlike its related protein, heart and thyroid, is a cytoplasmic Rab GTPase effector, liver, ovary, pancreas, rabphilin-3A, rabphilin-3AL can also bind Rab 3 and Rab 8 with its RBD domain, rabphilin-3AL can inhibit G-protein signaling in endocrine pancreas and positively regulate insulin secretion, rabphilin-3AL does not contain any C2 domains, rabphilin-3AL is capable of binding Rab 27a and, rabphilin-3AL is recruited to dense-core vesicles, skeletal muscle, stomach, through this interaction, with highest levels found in kidney, Rabphilin-3AL (rabphilin-3A-like) |
| Purification method: |
Purified by Protein A |
| Storage: |
50% glycerol and 0, Store at 4°, 09% sodium azide, C for 12 months, Water buffered solution containing 100ug/ml BSA |
| Excitation emission: |
590nm/617nm |
| Synonyms: |
Noc2 |
| Also known as: |
RPH3AL Polyclonal Antibody |
| Other name: |
Anti-RPH3AL Polyclonal |
| Advisory: |
For antibodies that are in liquid form or reconstituted lyophilized antibodies small amounts could become entrapped on the seal or the walls of the tube, Prior to use briefly centrifuge the vial to gather all the solution on the bottom, specificity and sensitivity, thus reducing its reactivity, Avoid freeze/thaw cycles as they may denaturate the polypeptide chains of the antibody |
| Properties: |
For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Group: |
Polyclonals and antibodies |
| About: |
The advantage is that there are more epitopes available in a polyclonal antiserum to detect the proteins than in monoclonal sera, immunohistochemistry on frozen slices or parrafin fixed tissues, Polyclonals can be used for Western blot |
| Gene target: |
RPH3AL |
| Short name: |
Anti-RPH3AL (Polyclonal) Fluor 594 |
| Technique: |
Pabs are a collection of immunoglobulin , Polyclonal antibodies , each identifying a different , whereas , (pAbs) are mostly rabbit or goat , B cells, Polyclonal, antibodies , antigen, come from a single N cell lineage, epitope, molecules that react against a specific , monoclonal antibodies , that are secreted by different |
| Label: |
ALEXA |
| Alternative name: |
ALEXA Fluor 594, antibody to-rabphilin 3A-like (without complement component 2 domains) (polyclonal) |
| Alternative technique: |
polyclonals |
| Alternative to gene target: |
Cytoplasm, NOC2, RPH3AL and IDBG-13853 and ENSG00000181031 and 9501, RPH3AL and IDBG-632666 and ENSBTAG00000039819 and 617294, Rph3al and IDBG-200631 and ENSMUSG00000020847 and 380714, metal ion binding, this GO :0005515 and protein binding and molecular function this GO :0005737 and cytoplasm and cellular component this GO :0006886 and intracellular protein transport and biological process this GO :0006887 and exocytosis and biological process this GO :0008092 and cytoskeletal protein binding and molecular function this GO :0017137 and Rab GTPase binding and molecular function this GO :0017158 and regulation of calcium ion-dependent exocytosis and biological process this GO :0030141 and secretory granule and cellular component this GO :0030274 and LIM domain binding and molecular function this GO :0030658 and transport vesicle membrane and cellular component this GO :0030667 and secretory granule membrane and cellular component this GO :0042493 and response to drug and biological process this GO :0042593 and glucose homeostasis and biological process this GO :0045744 and negative regulation of G-protein coupled receptor protein signaling pathway and biological process this GO :0046872 and metal ion binding and molecular function this GO :0050714 and positive regulation of protein secretion and biological process, this GO :0005515 : protein binding, this GO :0005515 : protein binding and also this GO :0008092 : cytoskeletal protein binding and also this GO :0017137 : Rab GTPase binding and also this GO :0030274 : LIM domain binding and also this GO :0046872 : metal ion binding, this GO :0008092 : cytoskeletal protein binding, this GO :0017137 : Rab GTPase binding, this GO :0030274 : LIM domain binding, this GO :0046872 : metal ion binding, rabphilin 3A-like (without C2 domains) |
| Identity: |
10296 |
| Gene: |
RPH3AL |
More about : RPH3AL |
| Long gene name: |
rabphilin 3A-like (without C2 domains) |
| Locus: |
17p13, 3 |
| Discovery year: |
1999-04-14 |
| Entrez gene record: |
9501 |
| Pubmed identfication: |
10395805 |
| RefSeq identity: |
NM_006987 |
| Havana BLAST/BLAT: |
OTTHUMG00000090273 |