| Long name: |
ALEXA FLUOR 350 Conjugated, APG5L Polyclonal Antibody |
| Also known as: |
Anti-APG5L PAb ALEXA FLUOR 350 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
350, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
APG5L |
| Specificity: |
This is a highly specific antibody against APG5L |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
118-158/275 |
| Subcellular location: |
Membrane bound, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human APG5L |
| Gene ID Number: |
9474 |
| Swiss Prot: |
Q9H1Y0 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus, Conjugation with ATG12, Involved in mitochondrial quality control after oxidative damage, Involved in the maintenance of axon morphology and membrane structures, Its expression is a relatively late event in the apoptotic process, May play an important role in the apoptotic process, Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation, Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD, Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT2 via the autophagic pathway, Required for optimal processing and presentation of antigens for MHC II, The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes, The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS, and in subsequent cellular longevity, as well as in normal adipocyte differentiation, is essential for its function, occurring downstream of caspase activity, possibly within the modified cytoskeleton, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG1 as an E2-like conjugating enzyme, Involved in autophagic vesicle formation |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
343nm/442nm |
| Synonyms: |
ASP APG5 hAPG5 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 350, Alexa Fluor |
| Gene target: |
APG5L |
| Short name: |
APG5L Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 350 |
| Alternative name: |
ALEXA FLUOR 350, APG5L (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
589 |
| Gene: |
ATG5 |
More about : ATG5 |
| Long gene name: |
autophagy related 5 |
| Synonyms gene: |
APG5L |
| Synonyms gene name: |
APG5 (autophagy 5, S, cerevisiae) , cerevisiae) ATG5 autophagy related 5 homolog (S, cerevisiae)-like APG5 autophagy 5-like (S |
| Locus: |
6q21 |
| Discovery year: |
1999-09-16 |
| GenBank acession: |
Y11588 |
| Entrez gene record: |
9474 |
| Pubmed identfication: |
9563500 11349150 15778222 |
| RefSeq identity: |
NM_004849 |
| Classification: |
Autophagy related |
| Havana BLAST/BLAT: |
OTTHUMG00000016193 |