| Long name: |
ALEXA FLUOR 350 Conjugated, MAP3K8 Polyclonal Antibody |
| Also known as: |
Anti-MAP3K8 PAb ALEXA FLUOR 350 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
350, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
MAP3K8 |
| Specificity: |
This is a highly specific antibody against MAP3K8 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
140-190/467 |
| Subcellular location: |
Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MAP3K8 |
| Gene ID Number: |
1326 |
| Swiss Prot: |
P41279 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
In adipocytes, In vitro, Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production, Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells, Isoform 1 shows some transforming activity, May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types, Plays a role in the cell cycle, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, although it is much weaker than that of the activated oncogenic variant, and thus may play a role in the regulation of immunoglobulin production, but not insulin, leading to induction of lipolysis, leading to up-regulation of IL8 and CCL4, thus being critical for production of the proinflammatory cytokine TNF-alpha (TNF) during immune responses, Required for lipopolysaccharide (LPS)-induced |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
343nm/442nm |
| Synonyms: |
Tpl-2 EST c-COT MEKK8 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 350 conjugates can be used in multi-color flow cytometry with FACS's equipped with a second red laser or red diode, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 350, Alexa Fluor |
| Gene target: |
MAP3K8 |
| Short name: |
MAP3K8 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 350 |
| Alternative name: |
ALEXA FLUOR 350, MAP3K8 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
6860 |
| Gene: |
MAP3K8 |
More about : MAP3K8 |
| Long gene name: |
mitogen-activated protein kinase kinase kinase 8 |
| Synonyms gene: |
COT ESTF |
| Locus: |
10p11, 23 |
| Discovery year: |
1992-09-14 |
| GenBank acession: |
D14497 |
| Entrez gene record: |
1326 |
| Pubmed identfication: |
2072910 8479752 |
| RefSeq identity: |
NM_005204 |
| Classification: |
Mitogen-activated protein kinase kinase kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000017889 |