| Long name: |
ALEXA FLUOR 555 Conjugated, KAP1 Polyclonal Antibody |
| Also known as: |
Anti-KAP1 PAb ALEXA FLUOR 555 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
555, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
KAP1 |
| Specificity: |
This is a highly specific antibody against KAP1 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
650-700/835 |
| Subcellular location: |
Nucleus |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human KAP1/TIF1b |
| Gene ID Number: |
10155 |
| Swiss Prot: |
Q13263 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Also corepressor for ERBB4, Also specifically sumoylates IRF7, Enhances transcriptional repression by coordinating the increase in H3K9me, Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger, Important regulator of CDKN1A/p21(CIP1), Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation, May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1, May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1, Mediates gene silencing by recruiting CHD3, Mediates the nuclear localization of KOX1, Recruitment of SETDB1 induces heterochromatinization, Ubiquitinates p53/TP53 leading to its proteosomal degradation, ZNF268 and ZNF300 transcription factors, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes, and possibly MAGEA3 and MAGEA6, respectively) and the disposition of HP1 proteins to silence gene expression, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, the function is enhanced by MAGEC2 and MAGEA2, thereby inhibiting its transactivation activity, Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs) |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
553nm/568nm |
| Synonyms: |
TIF1B KAP1 TF1B RNF96 PPP1R157 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, Very high photo stable ALEXA conjugate, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
ALEXA FLUOR 555, Alexa Fluor |
| Gene target: |
KAP1 |
| Short name: |
KAP1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 555 |
| Alternative name: |
ALEXA FLUOR 555, KAP1 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
16384 |
| Gene: |
TRIM28 |
More about : TRIM28 |
| Long gene name: |
tripartite motif containing 28 |
| Synonyms gene name: |
tripartite motif-containing 28 |
| Synonyms name: |
protein phosphatase 1, regulatory subunit 157 |
| Locus: |
19q13, 4 |
| Discovery year: |
2001-08-10 |
| Entrez gene record: |
10155 |
| Pubmed identfication: |
11331580 11226167 |
| RefSeq identity: |
NM_005762 |
| Classification: |
Tripartite motif containing PHD finger proteins Ring finger proteins Protein phosphatase 1 regulatory subunits |
| Havana BLAST/BLAT: |
OTTHUMG00000183546 |