SHC Antibody, ALEXA FLUOR 594

Catalog number:	bs-3572R-A594 Buy Now
Price:	465 €
Supplier:	Bluegen antibodies
Product name:	SHC Antibody, ALEXA FLUOR 594
Quantity:	200ug (50ug, 100ug available)
Related search:	shc alexa antibody pshc antibodies signaling synonyms deg

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Long name:	ALEXA FLUOR 594 Conjugated, SHC Polyclonal Antibody
Also known as:	Anti-SHC PAb ALEXA FLUOR 594
Category:	Conjugated Primary Antibodies
Conjugated with:	594, ALEXA FLUOR®
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	SHC
Specificity:	This is a highly specific antibody against SHC
Modification:	Unmodified
Modification Site:	None
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen range:	480-520/583
Subcellular location:	Cytoplasm
Source:	This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human SHC
Gene ID Number:	6464
Swiss Prot:	P29353
Tested applications:	IF(IHC-P)
Recommended dilutions:	IF(IHC-P)(1:50-200)
Crossreactivity:	Mouse, Rat, Human
Cross-reactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen:	Isoform p46Shc and isoform p52Shc, Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems, Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, Isoform p66Shc does not mediate Ras activation, Participates in a signaling cascade initiated by activated KIT and KITLG/SCF, Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, The expression of isoform p66Shc has been correlated with life span (By similarity), and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals, cytochrome c release and apoptosis, once phosphorylated, Signaling adapter that couples activated growth factor receptors to signaling pathways
Purification:	Purified by Protein A
Storage conditions:	50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission:	590nm/617nm
Synonyms:	p66 ShcA
Properties:	ALEXA FLUOR they should be stored frozen at - 24°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation:	594, ALEXA FLUOR®, Alexa Fluor
Conjugated:	Alexa conjugate 1
Gene target:	SHC
Short name:	SHC Antibody
Technique:	antibodies against human proteins, antibodies for, Antibody
Label:	ALEXA FLUOR 594
Alternative name:	ALEXA FLUOR 594, SHC (Antibody to)
Alternative technique:	antibodies
Identity:	10840
Gene:	SHC1 | More about : SHC1
Long gene name:	SHC adaptor protein 1
Synonyms gene:	SHC
Synonyms gene name:	SHC (Src homology 2 domain-containing) transforming protein 1
Locus:	1q21, 3
Discovery year:	1993-02-17
GenBank acession:	U73377
Entrez gene record:	6464
Pubmed identfication:	1623525
RefSeq identity:	NM_183001
Classification:	SH2 domain containing
Havana BLAST/BLAT:	OTTHUMG00000037295

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