| Long name: |
Rsk2 Primary Polyclonal Antibody |
| Also known as: |
Rsk2 PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
Rsk2 |
| Specificity: |
This is a highly specific antibody against Rsk2 |
| Modification(s): |
None |
| Modification site(s): |
Unmodified antibody |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
80-130/740 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human Rsk2/MAPKAP Kinase 1b |
| Gene ID number: |
6197 |
| Swiss Prot: |
P51812 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
ETV1/ER81 and NR4A1/NUR77, In fibroblast, In response to insulin, In response to mitogenic stimulation (EGF and PMA), Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function, Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex, Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4), Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1, and mediates cellular proliferation, and mediates phosphorylation of RPTOR, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', phosphorylates EIF4B, phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP, regulates translation through RPS6 and EIF4B phosphorylation, survival, which potently inhibits TSC2 ability to suppress mTOR signaling, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway, which results in the subsequent transcriptional activation of several immediate-early genes, Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1 |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
90 kDa ribosomal protein S6 kinase 3, ISPK-1, ISPK1, Insulin-stimulated protein kinase 1, MAP kinase-activated protein kinase 1b, MAPK-activated protein kinase 1b, MAPKAP kinase 1b, MAPKAPK-1b, MAPKAPK1B, RPS6KA3, RSK-2, RSK2, Ribosomal S6 kinase 2, S6K-alpha-3, p90-RSK 3, p90RSK3, pp90RSK2, Ribosomal protein S6 kinase alpha-3 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Rsk2 |
| Short name: |
Rsk2 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
Rsk2 (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
2089 |
| Gene: |
CLS |
More about : CLS |
| Long gene name: |
ribosomal protein S6 kinase A3 |
| Synonyms gene: |
MRX19 |
| Synonyms gene name: |
90kD, polypeptide 3 , ribosomal protein S6 kinase |
| Synonyms: |
RSK RSK2 HU-3 RPS6KA3 |
| Locus: |
Xp22, 12 |
| Discovery year: |
1994-07-11 |
| GenBank acession: |
U08316 |
| Entrez gene record: |
6197 |
| Pubmed identfication: |
8141249 11896450 16879200 |
| RefSeq identity: |
NM_004586 |
| Classification: |
X-linked mental retardation Mitogen-activated protein kinase-activated protein kinases |
| Havana BLAST/BLAT: |
OTTHUMG00000021231 |
| Locus Specific Databases: |
Mental Retardation database |