| Long name: |
Biotin Conjugated, Pin1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
Pin1 |
| Specificity: |
This is a highly specific antibody against Pin1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Source: |
KLH conjugated synthetic peptide derived from human Pin1 |
| Gene ID number: |
5300 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Peptidyl-prolyl isomerases (PPIase) facilitate the cis-trans interconversion of the peptidyl-prolyl bond thereby affecting protein folding, Pin1 binds to tau phosphorylated specifically on the Thr231-Pro site and induces conformational changes in tau, Pin1 could be pivotal for maintainance of normal neuronal function and preventing age-dependent neurodegeneration, Pin1 expression inversely correlates with the predicted neuronal vulnerability in normally aged brain and also with actual neurofibrillary degeneration in AD brain, Pin1 has been implicated in tau pathologies that underlie Alzheimer's Disease, Pin1 is a PPIase which specifically recognizes phosphorylated S/T-P bonds, Such conformational changes can directly restore the ability of phosphorylated Tau to bind microtubules and promote microtubule assembly and/or facilitate tau dephosphorylation, Pin1 is a Peptidyl-prolyl isomerases (PPIase) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
NIMA interacting 1, PIN1_HUMAN, PPIase Pin1, Peptidyl prolyl cis trans isomerase NIMA interacting 1, Peptidyl prolyl cis/trans isomerase NIMA interacting, Pin 1, Prolyl isomerase, Protein NIMA interacting 1, Protein peptidylprolyl cis/trans isomerase NIMA interacting 1, Rotamase Pin1, UBL 5, UBL5, DOD |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
Pin1 Conjugated |
| Short name: |
Conjugated, Pin1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
NIMA-interacting 1 (Antibody to), biotinilated coupled, peptidylprolyl cis/trans isomerase |
| Alternative technique: |
antibodies |