| Long name: |
FITC Conjugated, MST1 Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Anti-FITC Antibody |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
MST1 |
| Specificity: |
This is a highly specific antibody against MST1 |
| Modification: |
Unmodified |
| Modification site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
400-450/487 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
KLH conjugated synthetic peptide derived from human MST1 |
| Gene ID number: |
6789 |
| Swiss Prot: |
Q13043 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Acts as an inhibitor of PKB/AKT1, Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis, MOBKL1B and RASSF2, Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis, Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes, Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner, Phosphorylates FOXO3 upon oxidative stress, Phosphorylates MOBKL1A, Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T), Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, and cell migration, and to inhibit tumor formation (By similarity), cell death, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation, following caspase-cleavage, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, pro-apoptotic kinase which, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage, to prevent activation of facultative adult liver stem cells (oval cells), which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ, which results in its nuclear translocation and cell death initiation, Stress-activated |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Excitation Emission: |
494nm/518nm |
| Synonyms: |
MST1 KRS2 YSK3 |
| Properties: |
Bioss Primary Conjugated Antibodies FITC is highly sensitive to pH extremes, FITC has a green emission that's usually collected at 530 nanometers, FITC has a high quantum yield (efficiency of energy transfer from absorption to emission fluorescence) and approximately half of the absorbed photons are emitted as fluorescent light, For fluorescent microscopy applications, This Bioss Primary Conjugated Antibodies Fluorescein isothiocyanate (FITC) antibody is currently after some BD antibodies the most commonly used fluorescent dye for FACS, When excited at 488 nanometers, its photo bleaching effects are not observed due to a very brief interaction at the laser intercept, the 1 FITC is seldom used as it photo bleaches rather quickly though in flow cytometry applications, the FL1 detector of a FACSCalibur or FACScan, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
MST1 Conjugated |
| Short name: |
FITC Conjugated, MST1 Antibody |
| Technique: |
Fluorescein, antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
FITC |
| Alternative name: |
fluorecein coupled, macrophage stimulating 1 (hepatocyte growth factor-like) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, D3F15S2 and DNF15S2 and HGFL and MSP and NF15S2, MST1 and IDBG-35033 and ENSG00000173531 and 4485, Mst1 and IDBG-199175 and ENSMUSG00000032591 and 15235, multiple, serine-type endopeptidase activity, this GO :0003674 and molecular function and molecular function this GO :0003824 and catalytic activity and molecular function this GO :0004252 and serine-type endopeptidase activity and molecular function this GO :0006508 and proteolysis and biological process this GO :0007283 and spermatogenesis and biological process this GO :0007566 and embryo implantation and biological process this GO :0008150 and biological process and biological process this GO :0030317 and sperm motility and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0003674 : molecular_function, this GO :0003674 : molecular_function and also this GO :0003824 : catalytic activity and also this GO :0004252 : serine-type endopeptidase activity, this GO :0003824 : catalytic activity, this GO :0004252 : serine-type endopeptidase activity, 60953 and IDBG-645967 and ENSBTAG00000011585 and 514667, macrophage stimulating 1 (hepatocyte growth factor-like) |
| Identity: |
11408 |
| Gene: |
STK4 |
More about : STK4 |
| Long gene name: |
serine/threonine kinase 4 |
| Synonyms name: |
mammalian sterile 20-like 1 yeast Ste20-like kinase responsive to stress 2 |
| Locus: |
20q13, 12 |
| Discovery year: |
1997-10-09 |
| Entrez gene record: |
6789 |
| Pubmed identfication: |
8816758 9545236 11517310 |
| RefSeq identity: |
NM_006282 |
| Havana BLAST/BLAT: |
OTTHUMG00000033059 |
| Locus Specific Databases: |
LRG_535 |