| Long name: |
ALEXA FLUOR 488 Conjugated, MST1 Polyclonal Antibody |
| Also known as: |
Anti-MST1 PAb ALEXA FLUOR 488 |
| Category: |
Conjugated Primary Antibodies |
| Conjugated with: |
488, ALEXA FLUOR® |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
MST1 |
| Specificity: |
This is a highly specific antibody against MST1 |
| Modification: |
Unmodified |
| Modification Site: |
None |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
400-450/487 |
| Subcellular location: |
Nucleus, Cytoplasm |
| Source: |
This antibody was obtained by immunization of the host with KLH conjugated synthetic peptide derived from human MST1 |
| Gene ID Number: |
6789 |
| Swiss Prot: |
Q13043 |
| Tested applications: |
IF(IHC-P) |
| Recommended dilutions: |
IF(IHC-P)(1:50-200) |
| Crossreactivity: |
Mouse, Rat, Human |
| Cross-reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the antigen: |
Acts as an inhibitor of PKB/AKT1, Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis, MOBKL1B and RASSF2, Phosphorylates 'Ser-14' of histone H2B (H2BS14ph) during apoptosis, Phosphorylates AR on 'Ser-650' and suppresses its activity by intersecting with PKB/AKT1 signaling and antagonizing formation of AR-chromatin complexes, Phosphorylates FOXO1 on 'Ser-212' and regulates its activation and stimulates transcription of PMAIP1 in a FOXO1-dependent manner, Phosphorylates FOXO3 upon oxidative stress, Phosphorylates MOBKL1A, Phosphorylates SIRT1 and inhibits SIRT1-mediated p53/TP53 deacetylation, Phosphorylates TNNI3 (cardiac Tn-I) and alters its binding affinity to TNNC1 (cardiac Tn-C) and TNNT2 (cardiac Tn-T), Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, and cell migration, and to inhibit tumor formation (By similarity), cell death, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation, following caspase-cleavage, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, pro-apoptotic kinase which, thereby promoting p53/TP53 dependent transcription and apoptosis upon DNA damage, to prevent activation of facultative adult liver stem cells (oval cells), which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ, which results in its nuclear translocation and cell death initiation, Stress-activated |
| Purification: |
Purified by Protein A |
| Storage conditions: |
50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA |
| Excitation emission: |
499nm/519nm |
| Synonyms: |
MST1 KRS2 YSK3 |
| Properties: |
ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 488 has the same range to that of fluorescein isothiocyanate (FITC), Also Alexa Fluor 488 is pH stable, As a result of this photo stability, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is distinguished in the FL1 of a FACS-Calibur or FACScan, has a very high photo stability, it has turned into an antibody for fluorescent microscopy and FACS FLOW cytometry, yet the MST1 Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate |
| Conjugation: |
Alexa Fluor |
| Gene target: |
MST1 |
| Short name: |
MST1 Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Label: |
ALEXA FLUOR 488 |
| Alternative name: |
ALEXA FLUOR 488, macrophage stimulating 1 (hepatocyte growth factor-like) (Antibody to) |
| Alternative technique: |
antibodies |
| Alternative to gene target: |
BT, D3F15S2 and DNF15S2 and HGFL and MSP and NF15S2, MST1 and IDBG-35033 and ENSG00000173531 and 4485, Mst1 and IDBG-199175 and ENSMUSG00000032591 and 15235, multiple, serine-type endopeptidase activity, this GO :0003674 and molecular function and molecular function this GO :0003824 and catalytic activity and molecular function this GO :0004252 and serine-type endopeptidase activity and molecular function this GO :0006508 and proteolysis and biological process this GO :0007283 and spermatogenesis and biological process this GO :0007566 and embryo implantation and biological process this GO :0008150 and biological process and biological process this GO :0030317 and sperm motility and biological process this GO :0070062 and extracellular vesicular exosome and cellular component, this GO :0003674 : molecular_function, this GO :0003674 : molecular_function and also this GO :0003824 : catalytic activity and also this GO :0004252 : serine-type endopeptidase activity, this GO :0003824 : catalytic activity, this GO :0004252 : serine-type endopeptidase activity, 60953 and IDBG-645967 and ENSBTAG00000011585 and 514667, macrophage stimulating 1 (hepatocyte growth factor-like) |
| Identity: |
11408 |
| Gene: |
STK4 |
More about : STK4 |
| Long gene name: |
serine/threonine kinase 4 |
| Synonyms name: |
mammalian sterile 20-like 1 yeast Ste20-like kinase responsive to stress 2 |
| Locus: |
20q13, 12 |
| Discovery year: |
1997-10-09 |
| Entrez gene record: |
6789 |
| Pubmed identfication: |
8816758 9545236 11517310 |
| RefSeq identity: |
NM_006282 |
| Havana BLAST/BLAT: |
OTTHUMG00000033059 |
| Locus Specific Databases: |
LRG_535 |