Smad3 (Ser423 + Ser425) Antibody, ALEXA FLUOR 647

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Catalog number: bs-3425R-A647
Price: 368 €
Supplier: Bioss Primary Conjugated Antibodies
Product name: Smad3 (Ser423 + Ser425) Antibody, ALEXA FLUOR 647
Quantity: 0.1ml
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Long name: ALEXA FLUOR 647 Conjugated, Smad3 (Ser423 + Ser425) Antibody
Also known as: Anti-Smad3 Ser423 + Ser425 PAb ALEXA FLUOR 647
Category: Conjugated Primary Antibodies
Conjugated with: 647, ALEXA FLUOR®
Host Organism: Rabbit (Oryctolagus cuniculus)
Target Antigen: Smad3 Ser423 + Ser425
Specificity: This is a highly specific antibody against Smad3 Ser423 + Ser425
Modification: Phosphorylation
Modification Site: Ser423 + Ser425
Clonality: Polyclonal
Clone: Polyclonal antibody
Concentration: 1ug per 1ul
Immunogen range: 380-425/425
Subcellular location: Nucleus, Cytoplasm
Source: KLH conjugated synthetic phosphopeptide derived from human Smad3 around the phosphorylation site of Ser423/425 [CS(p-S)V(p-S)]
Gene ID Number: 4088
Swiss Prot: P84022
Tested applications: IF(IHC-P)
Recommended dilutions: IF(IHC-P)(1:50-200)
Crossreactivity: Mouse, Rat, Human
Cross-reactive species details: not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Background of the antigen: Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription, Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes, Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator, Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures, This effect on wound healing appears to be hormone-sensitive, activates transcription, on formation of the SMAD3/SMAD4 complex, Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases
Purification: Purified by Protein A
Storage conditions: 50% glycerol and 0, Keep refrigerated at 2 to 8 degrees Celcius for up to one year, 09% sodium azide, Store this antibody in aqueous buffered solution containing 1% BSA
Excitation emission: 650nm/665nm
Synonyms: HSPC193, HsT17436, JV15-2, LDS1C, MAD homolog 3, MADH3, Mad3, Mothers against DPP homolog 3, Mothers against decapentaplegic homolog 3, SMAD 3, SMAD family member 3, Smad3, hMAD-3, hSMAD3, LDS3
Properties: ALEXA FLUOR made this Alexa Fluor 633 conjugate that can be used in multi-color flow cytometry with instruments equipped with a second red laser or red diode, ALEXA FLUOR they should be stored frozen at - 24°, Alexa Fluor 633 is a practical alternative to APC as well as Cy5, Bioss Primary Conjugated Antibodies, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies, It is detected in the FL4 detector of the core's upgraded 2-laser FACScans, Like other Alexa Fluor dyes, exhibits uncommon photo stability, making it an ideal choice for fluorescent microscopy, the Smad3 (Ser423 + Ser425) Antibody, C, C for long term storage and for short term at + 5°, For facs or microscopy Alexa 1 conjugate
Conjugation: ALEXA FLUOR 647, Alexa Fluor
Gene target: Smad3 (Ser423 + Ser425)
Short name: Smad3 (Ser423 + Ser425) Antibody
Technique: antibodies against human proteins, antibodies for, Antibody
Label: ALEXA FLUOR 647
Alternative name: ALEXA FLUOR 647, SMAD family member 3 (Ser423 and Ser425) (Antibody to)
Alternative technique: antibodies

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