Smad3 (Ser423 + Ser425) Antibody, Biotin Conjugated

Catalog number:	bs-3425R-Biotin Buy Now
Price:	350 €
Supplier:	Bioss Primary Conjugated Antibodies.
Product name:	Smad3 (Ser423 + Ser425) Antibody, Biotin Conjugated
Quantity:	100ul
Related search:	ser smad antibody antibodies biotin homolog streptavidin

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Long name:	Biotin Conjugated, Smad3 (Ser423 + Ser425) Antibody
Category:	Conjugated Primary Antibodies
Conjugation:	Biotinylated
Host Organism:	Rabbit (Oryctolagus cuniculus)
Target Antigen:	Smad3 Ser423 + Ser425
Specificity:	These phosphorylation sites are homologous across the species listed, This is a highly specific antibody against Smad3 Ser423 + Ser425
Modification:	Phosphorylation
Modification site:	Ser423 + Ser425
Clonality:	Polyclonal
Clone:	Polyclonal antibody
Concentration:	1ug per 1ul
Immunogen_range:	380-425/425
Subcellular location:	Nucleus, Cytoplasm
Source:	KLH conjugated synthetic phosphopeptide derived from human Smad3 around the phosphorylation site of Ser423/425 [CS(p-S)V(p-S)]
Gene ID number:	4088
Swiss Prot:	P84022
Tested applications:	IHC-P, WB
Recommended dilutions:	IHC-P(1:100-500), WB(1:100-1000)
Crossreactivity:	Mouse, Rat, Human
Crossreactive species details:	not every possible cross-reactivity is known, Due to limited amount of testing and knowledge
Antigen background:	Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription, Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes, Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator, Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures, This effect on wound healing appears to be hormone-sensitive, activates transcription, on formation of the SMAD3/SMAD4 complex, Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases
Purification method:	This antibody was purified via Protein A
Storage conditions:	50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA
Synonyms:	HSPC193, HsT17436, JV15-2, LDS1C, MAD homolog 3, MADH3, Mad3, Mothers against DPP homolog 3, Mothers against decapentaplegic homolog 3, SMAD 3, SMAD family member 3, Smad3, hMAD-3, hSMAD3, LDS3
Properties:	Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°
Gene target:	Smad3 (Ser423 + Ser425) Conjugated
Short name:	Conjugated, Smad3 (Ser423 + Ser425) Antibody
Technique:	antibodies against human proteins, antibodies for, antibody Conjugates, Antibody
Label:	Biotin
Alternative name:	biotinilated coupled, SMAD family member 3 (Ser423 and Ser425) (Antibody to)
Alternative technique:	antibodies

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