| Long name: |
Biotin Conjugated, TIF1 beta(Ser824) Polyclonal Antibody |
| Category: |
Conjugated Primary Antibodies |
| Conjugation: |
Biotinylated |
| Host Organism: |
Rabbit (Oryctolagus cuniculus) |
| Target Antigen: |
T1 beta Ser824 |
| Specificity: |
This phosphorylation site is homologous across the listed species, This is a highly specific antibody against T1 beta Ser824 |
| Modification: |
Phosphorylation |
| Modification site: |
Ser824 |
| Clonality: |
Polyclonal |
| Clone: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen_range: |
790-835/835 |
| Subcellular location: |
Nucleus |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human TIF1 beta around the phosphorylation site of Ser824 |
| Gene ID number: |
10155 |
| Swiss Prot: |
Q13263 |
| Tested applications: |
IHC-P, WB |
| Recommended dilutions: |
IHC-P(1:100-500), WB(1:100-1000) |
| Crossreactivity: |
Mouse, Rat, Human |
| Crossreactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Antigen background: |
Also corepressor for ERBB4, Also specifically sumoylates IRF7, Enhances transcriptional repression by coordinating the increase in H3K9me, Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger, Important regulator of CDKN1A/p21(CIP1), Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation, May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1, May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1, Mediates gene silencing by recruiting CHD3, Mediates the nuclear localization of KOX1, Recruitment of SETDB1 induces heterochromatinization, Ubiquitinates p53/TP53 leading to its proteosomal degradation, ZNF268 and ZNF300 transcription factors, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes, and possibly MAGEA3 and MAGEA6, respectively) and the disposition of HP1 proteins to silence gene expression, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, the function is enhanced by MAGEC2 and MAGEA2, thereby inhibiting its transactivation activity, Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store refrigerated at 2 to 8 degrees Celcius for up to 1 year, 09% sodium azide, Keep the antibody in an aqueous buffered solution containing 1% BSA |
| Synonyms: |
hTIF1 Tif1a RNF82 TIF1A |
| Properties: |
Avidin and Streptavidin bind to the small biotin and are couple to HRP or AP for ELISA, Biotin conjugates can be detected by horseradish peroxidase, To break the streptavidin Biotin bond we suggest to use a 6 molar guanidine HCl solution with acidity of pH 1, alkaline phosphatase substrates or anti biotin conjugated antibodies, 6, C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
TIF1 beta(Ser824) Conjugated |
| Short name: |
Conjugated, TIF1 beta(Ser824) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, antibody Conjugates, Antibody |
| Label: |
Biotin |
| Alternative name: |
biotinilated coupled, TIF1 b(Ser824) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11812 |
| Gene: |
TRIM24 |
More about : TRIM24 |
| Long gene name: |
tripartite motif containing 24 |
| Synonyms gene: |
TIF1 |
| Synonyms gene name: |
transcriptional intermediary factor 1 tripartite motif-containing 24 |
| Locus: |
7q33-q34 |
| Discovery year: |
1998-12-18 |
| GenBank acession: |
AF009353 |
| Entrez gene record: |
8805 |
| Pubmed identfication: |
9115274 9191165 |
| RefSeq identity: |
NM_015905 |
| Classification: |
Tripartite motif containing PHD finger proteins Ring finger proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000155820 |