| Long name: |
TIF1 beta(Ser824) Primary Polyclonal Antibody |
| Also known as: |
TIF1 beta(Ser824) PAb |
| Category: |
Primary Antibodies |
| Conjugation: |
Unconjugated |
| Target Antigen: |
T1 beta Ser824 |
| Specificity: |
This phosphorylation site is homologous across the listed species, This is a highly specific antibody against T1 beta Ser824 |
| Modification(s): |
Phosphorylation |
| Modification site(s): |
Ser824 |
| Clonality: |
Polyclonal antibody |
| Clone number: |
Polyclonal antibody |
| Concentration: |
1ug per 1ul |
| Immunogen range: |
790-835/835 |
| Subcellular location: |
Nucleus |
| Source: |
KLH conjugated synthetic phosphopeptide derived from human TIF1 beta around the phosphorylation site of Ser824 |
| Gene ID number: |
10155 |
| Swiss Prot: |
Q13263 |
| Tested Applications: |
IF(IHC-P), IHC-P, WB |
| Recommended dilutions: |
IF(IHC-P)(1:50-200), IHC-P(1:100-500), WB(1:100-1000) |
| Cross reactivity: |
Mouse, Rat, Human |
| Cross reactive species details: |
not every possible cross-reactivity is known, Due to limited amount of testing and knowledge |
| Background of the target antigen: |
Also corepressor for ERBB4, Also specifically sumoylates IRF7, Enhances transcriptional repression by coordinating the increase in H3K9me, Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger, Important regulator of CDKN1A/p21(CIP1), Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation, May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1, May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1, Mediates gene silencing by recruiting CHD3, Mediates the nuclear localization of KOX1, Recruitment of SETDB1 induces heterochromatinization, Ubiquitinates p53/TP53 leading to its proteosomal degradation, ZNF268 and ZNF300 transcription factors, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes, and possibly MAGEA3 and MAGEA6, respectively) and the disposition of HP1 proteins to silence gene expression, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, the function is enhanced by MAGEC2 and MAGEA2, thereby inhibiting its transactivation activity, Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs) |
| Purification method: |
This antibody was purified via Protein A |
| Storage conditions: |
50% glycerol and 0, Store at -20°, 09% sodium azide, C for up to 1 year, Keep the antibody in aqueous buffered solution containing 1% BSA |
| Synonym names: |
E3 SUMO-protein ligase TRIM28, KAP-1, KRAB-associated protein 1, KRAB-interacting protein 1, KRIP-1, Nuclear corepressor KAP-1, PPP1R157, RING finger protein 96, RNF96, TF1B, TIF1-beta, TIF1B, TRIM28, Transcription intermediary factor 1-beta, Tripartite motif-containing protein 28, KAP1 |
| Properties: |
C, C for long term storage and for short term at + 5°, If you buy Antibodies supplied by Bioss Primary Unconjugated Antibodies they should be stored frozen at - 24° |
| Gene target: |
TIF1 beta(Ser824) |
| Short name: |
TIF1 beta(Ser824) Antibody |
| Technique: |
antibodies against human proteins, antibodies for, Antibody |
| Alternative name: |
TIF1 b(Ser824) (Antibody to) |
| Alternative technique: |
antibodies |
| Identity: |
11812 |
| Gene: |
TRIM24 |
More about : TRIM24 |
| Long gene name: |
tripartite motif containing 24 |
| Synonyms gene: |
TIF1 |
| Synonyms gene name: |
transcriptional intermediary factor 1 tripartite motif-containing 24 |
| Synonyms: |
hTIF1 Tif1a RNF82 TIF1A |
| Locus: |
7q33-q34 |
| Discovery year: |
1998-12-18 |
| GenBank acession: |
AF009353 |
| Entrez gene record: |
8805 |
| Pubmed identfication: |
9115274 9191165 |
| RefSeq identity: |
NM_015905 |
| Classification: |
Tripartite motif containing PHD finger proteins Ring finger proteins |
| Havana BLAST/BLAT: |
OTTHUMG00000155820 |